Masoud Khorrami-Nejad, Farshid Babapour Mofrad, Mahsa Ranjbar-Pazooki, Heirani Mohsen, Khodaparast Mehdi, Yousefi Reza
Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Saudi J Ophthalmol. 2024 Mar 1;39(2):198-205. doi: 10.4103/sjopt.sjopt_267_23. eCollection 2025 Apr-Jun.
The accuracy of optical biometry is higher than ocular ultrasound, but it is expensive and has limitations in patients with dense cataracts. On the other hand, ocular ultrasound biometry is still a frequently used technique in most developing countries due to its lower cost. Therefore, it could be helpful for practitioners to know the interchangeability of optical biometry devices with ultrasound biometry devices. This study is conducted to compare the axial length (AL), anterior chamber depth (ACD), and lens thickness (LT) measured by ocular optical and ultrasound biometers in different AL groups.
This prospective consecutive study was performed on 248 eyes of 248 patients. Ocular optical biometry was performed using IOLMaster 700 (swept-source optical coherence tomography-based optical biometry, Carl Zeiss, Germany), and the contact ultrasound biometry was carried out using the US-4000 Nidek Echoscan (Gamagori, Japan). Based on measured AL, patients were divided into three groups: the short eye (AL ≤22 mm), normal eye (22 < AL <24.5 mm), and long eye (AL ≥24.50 mm).
The agreement of AL between these biometers in all, short, normal, and long eyes was 99.9%, 98.3%, 99.6%, and 99.9%, respectively. The ACD agreement between two devices in all, short, normal, and long eyes was 97.0%, 93.8%, 97.2%, and 96.1%, respectively. Furthermore, the agreement of LT between these biometers in all, short, normal, and long eyes was 74.4%, 89.2%, 66.9%, and 90.7%, respectively. There were a very strong positive correlation in AL ( = 0.999) and ACD ( = 0.947) and a good correlation in LT ( = 0.675) between these devices (all < 0.001).
AL and ACD measured by the IOLMaster 700 optical biometer can be used interchangeably with the US-4000 ultrasound biometer in different AL groups. However, LT measured by these biometers cannot be used interchangeably.
光学生物测量的准确性高于眼部超声检查，但价格昂贵，且在白内障严重的患者中存在局限性。另一方面，由于成本较低，眼部超声生物测量在大多数发展中国家仍是一种常用技术。因此，了解光学生物测量设备与超声生物测量设备的互换性可能对从业者有所帮助。本研究旨在比较不同眼轴长度（AL）组中，眼部光学生物测量仪和超声生物测量仪测量的眼轴长度（AL）、前房深度（ACD）和晶状体厚度（LT）。
本前瞻性连续研究对248例患者的248只眼进行。使用IOLMaster 700（基于扫频光学相干断层扫描的光学生物测量仪，德国卡尔蔡司公司）进行眼部光学生物测量，使用US-4000 Nidek Echoscan（日本蒲郡）进行接触式超声生物测量。根据测量的眼轴长度，将患者分为三组：短眼（AL≤22mm）、正常眼（22＜AL＜24.5mm）和长眼（AL≥24.50mm）。
在所有眼、短眼、正常眼和长眼中，这些生物测量仪测量的眼轴长度一致性分别为99.9%、98.3%、99.6%和99.9%。两种设备在所有眼、短眼、正常眼和长眼中测量的前房深度一致性分别为97.0%、93.8%、97.2%和96.1%。此外，这些生物测量仪在所有眼、短眼、正常眼和长眼中测量的晶状体厚度一致性分别为74.4%、89.2%、66.9%和90.7%。这些设备之间的眼轴长度（r = 0.999）和前房深度（r = 0.947）呈非常强的正相关，晶状体厚度呈良好相关（r = 0.675）（均P＜0.001）。
在不同眼轴长度组中，IOLMaster 700光学生物测量仪测量的眼轴长度和前房深度可与US-4000超声生物测量仪互换使用。然而，这些生物测量仪测量的晶状体厚度不能互换使用。
