Minchin R F, McManus M E, Boobis A R, Davies D S, Thorgeirsson S S
Carcinogenesis. 1985 Dec;6(12):1721-4. doi: 10.1093/carcin/6.12.1721.
Two distinct phenotypes, slow and fast metabolizers, were observed for both metabolic activation and detoxification of the model chemical carcinogen, 2-acetylaminofluorene, in human liver microsomes from 28 individuals. We observed that individuals who were fast activators of the carcinogen were in most cases also fast detoxifiers of the chemical. However, different phenotype patterns exist suggesting that fast activators of a toxin need not also be phenotyped as fast detoxifiers. Studies in this area may help understand whether certain individuals are predisposed to a higher rate of chemically-induced cancers.
在来自28名个体的人肝微粒体中，对于模型化学致癌物2-乙酰氨基芴的代谢活化和解毒作用，观察到了两种不同的表型，即慢代谢型和快代谢型。我们观察到，那些对致癌物具有快速活化能力的个体，在大多数情况下也是该化学物质的快速解毒者。然而，存在不同的表型模式，这表明一种毒素的快速活化者不一定也被表型为快速解毒者。该领域的研究可能有助于了解某些个体是否更容易患化学诱导的癌症。
