Setogawa Susumu, Okauchi Takashi, Hu Di, Wada Yasuhiro, Hikishima Keigo, Onoe Hirotaka, Nishizawa Kayo, Sakayori Nobuyuki, Miyawaki Hiroyuki, Kitanishi Takuma, Mizuseki Kenji, Cui Yilong, Kobayashi Kazuto
Department of Physiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Department of Physiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Elife. 2025 Jul 11;13:RP97326. doi: 10.7554/eLife.97326.
The striatum, the central hub of cortico-basal ganglia loops, contains functionally heterogeneous subregions distinguished by the topographic patterns of structural connectivity. These subregions mediate various processes of procedural learning. However, it remains unclear when and how striatal subregions engage in the acquisition of sensory stimulus-based decision-making. A neuroimaging of regional brain activity shows that the anterior dorsolateral striatum (aDLS) and posterior ventrolateral striatum (pVLS) in rats are activated in a different temporal pattern during the acquisition phase of auditory discrimination. Chronic and transient pharmacologic manipulations show that the aDLS promotes the behavioral strategy driven by the stimulus-response association while suppressing that by the response-outcome association, and that the pVLS contributes to forming and maintaining the stimulus-response strategy. Electrophysiological recording indicates that subpopulations of aDLS neurons predominantly represent the outcome of specific behaviors at the initial period of discrimination learning, and that pVLS subpopulations encode the beginning and ending of each behavior according to the progress of learning. In addition, other subpopulations of striatal neurons indicate sustained activation after obtaining reward with distinct patterns reflecting the stimulus-response associations. Our findings demonstrate that aDLS and pVLS neurons integrate the new learning of auditory discrimination in spatiotemporally and functionally different manners.
纹状体作为皮质-基底神经节环路的中枢枢纽，包含功能异质性的亚区域，这些亚区域由结构连接的拓扑模式区分。这些亚区域介导程序性学习的各种过程。然而，尚不清楚纹状体亚区域何时以及如何参与基于感觉刺激的决策获取。一项区域脑活动的神经影像学研究表明，在大鼠听觉辨别学习的获取阶段，前背外侧纹状体（aDLS）和后背外侧纹状体（pVLS）以不同的时间模式被激活。长期和短暂的药理学操作表明，aDLS促进由刺激-反应关联驱动的行为策略，同时抑制由反应-结果关联驱动的行为策略，并且pVLS有助于形成和维持刺激-反应策略。电生理记录表明，aDLS神经元亚群在辨别学习初期主要代表特定行为的结果，并且pVLS亚群根据学习进程编码每种行为的开始和结束。此外，纹状体神经元的其他亚群在获得奖励后表现出持续激活，其不同模式反映了刺激-反应关联。我们的研究结果表明，aDLS和pVLS神经元以时空和功能上不同的方式整合听觉辨别的新学习。
