直肠癌中直肠系膜分级与肿瘤学结局的关联：一项系统评价与Meta分析

Association Between Mesorectal Grade and Oncologic Outcomes in Rectal Cancer: A Systematic Review and Meta-Analysis.

作者信息

Rogers Peter, Dourado Justin, Emile Sameh Hany, Wignakumar Anjelli, Delgado Zachary, Aeschbacher Pauline, Garoufalia Zoe, Strassmann Victor, Wexner Steven D

机构信息

Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.

Florida Atlantic University, College of Medicine, Department of General Surgery, Boca Raton, Florida, USA.

出版信息

J Surg Oncol. 2025 Sep;132(3):437-446. doi: 10.1002/jso.70038. Epub 2025 Jul 11.

We aimed to clarify the impact of TME grading on recurrence and survival. PubMed and Scopus were searched. The main outcome measures were local and distant recurrence and overall survival. Ten studies (2002-2023) were analyzed. Patients with incomplete TME exhibited lower overall survival (HR 0.75, p = 0.044) and higher local (RR 3.09, p = 0.001) and distant (RR 1.44, p = 0.005) recurrence rates compared to complete/near-complete TME. Complete and near-complete TME had similar risk of local recurrence, distant metastasis, and overall survival. This meta-analysis supports the crucial role of TME in rectal cancer outcomes.