Miller J M, Moxham J, Green M
Clin Sci (Lond). 1985 Jul;69(1):91-6. doi: 10.1042/cs0690091.
We studied diaphragm function in a total of 64 normal subjects, who had no past or present respiratory or neuromuscular impairment. We measured transdiaphragmatic pressure (Pdi) during maximal sniffs and compared these values with Pdi during maximal static inspiratory efforts (PImax.). The range of Pdi during maximal sniffs (82-204 cm H2O) had better defined lower limits than Pdi during PImax. (16-164 cm H2O) and a higher mean value: mean +/- SD for maximal sniffs was 137 +/- 28 cm H2O and for PImax. was 90 +/- 37 cm H2O. The reproducibility of sniff Pdi was assessed in eight randomly chosen subjects over 3 days: the mean coefficient of variation was 7.2%. By comparison the coefficient of variation of Pdi during PImax. was 13.0% in seven subjects. The maximal sniff is a spontaneous manoeuvre, easily performed, repeatable without tiring, and reproducible. Its measurement provides a more reliable quantitative method for assessment of diaphragm strength, which has potential in clinical practice.
我们对64名无既往或当前呼吸或神经肌肉损伤的正常受试者的膈肌功能进行了研究。我们测量了最大吸气时的跨膈压（Pdi），并将这些值与最大静态吸气努力时的Pdi（PImax）进行比较。最大吸气时Pdi的范围（82 - 204 cm H2O）比PImax时（16 - 164 cm H2O）具有更明确的下限，且平均值更高：最大吸气时的平均值±标准差为137 ± 28 cm H2O，PImax时为90 ± 37 cm H2O。在8名随机选择的受试者中，在3天内评估了吸气Pdi的可重复性：平均变异系数为7.2%。相比之下，7名受试者中PImax时Pdi的变异系数为13.0%。最大吸气是一种自发动作，易于执行，可重复且不累，具有可重复性。其测量为评估膈肌力量提供了一种更可靠的定量方法，在临床实践中具有潜力。
