关于人、豚鼠和大鼠免疫性和非免疫性产生的慢反应物质的比较研究。
Comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat.
作者信息
Morris H R, Piper P J, Taylor G W, Tippins J R
出版信息
Br J Pharmacol. 1979 Oct;67(2):179-84. doi: 10.1111/j.1476-5381.1979.tb08664.x.
Abstract
1 Slow-reacting substance of anaphylaxis (SRS-A) was produced by antigen challenge of passively sensitized human lung and actively sensitized guinea-pig lung. 2 A slow-reacting substance (SRS) was prepared from the peritoneal fluid of rats treated with calcium ionophore A23187. 3 These substances were extensively purified by charcoal adsorption, Sephadex G-15 gel filtration, ether extraction and reverse phase high pressure liquid chromatography. 4 The three substances are pharmacologically, chemically and chromatographically indistinguishable. 5 Our data suggest that the same SRS entities are released from a variety of tissues and that these acidic lipids may have a wider physiological significance than just anaphylaxis.
摘要
1 过敏反应迟缓反应物质（SRS-A）是通过对被动致敏的人肺和主动致敏的豚鼠肺进行抗原激发而产生的。2 一种迟缓反应物质（SRS）是从用钙离子载体A23187处理的大鼠腹腔液中制备的。3 这些物质通过活性炭吸附、葡聚糖凝胶G-15凝胶过滤、乙醚萃取和反相高压液相色谱法进行了广泛纯化。4 这三种物质在药理学、化学和色谱方面无法区分。5 我们的数据表明，相同的SRS实体从多种组织中释放出来，并且这些酸性脂质可能具有比过敏反应更广泛的生理意义。
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Comparative studies on immunologically and non-immunologically produced slow-reacting substances from man, guinea-pig and rat.关于人、豚鼠和大鼠免疫性和非免疫性产生的慢反应物质的比较研究。
Br J Pharmacol. 1979 Oct;67(2):179-84. doi: 10.1111/j.1476-5381.1979.tb08664.x.
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BIOLOGICALLY ACTIVE PRINCIPLES OCCURRING ON HISTAMINE RELEASE FROM CAT PAW, GUINEA PIG LUNG AND ISOLATED RAT MAST CELLS.从猫爪、豚鼠肺和分离的大鼠肥大细胞释放组胺过程中出现的生物活性成分。
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Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat.参与豚鼠和大鼠体内抗原诱导的过敏反应慢反应物质（SRS-A）释放的抗体。
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The release of prostaglandins and thromboxanes from guinea-pig lung by slow reacting substance of anaphylaxis, and its inhibition.豚鼠肺中过敏反应迟缓反应物质释放前列腺素和血栓素及其抑制作用
Br J Pharmacol. 1978 Oct;64(2):211-8. doi: 10.1111/j.1476-5381.1978.tb17291.x.
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Slow-reacting substance of anaphylaxis: purification and characterisation.过敏反应迟缓反应物质：纯化与特性鉴定
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Release of mediators of anaphylaxis: inhibition of prostaglandin synthesis and the modification of release of slow reacting substance of anaphylaxis and histamine.过敏反应介质的释放：前列腺素合成的抑制以及过敏反应慢反应物质和组胺释放的改变。
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Immunology. 1976 Nov;31(5):813-20.
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