豚鼠肺中过敏反应迟缓反应物质释放前列腺素和血栓素及其抑制作用
The release of prostaglandins and thromboxanes from guinea-pig lung by slow reacting substance of anaphylaxis, and its inhibition.
作者信息
Engineer D M, Morris H R, Piper P J, Sirois P
出版信息
Br J Pharmacol. 1978 Oct;64(2):211-8. doi: 10.1111/j.1476-5381.1978.tb17291.x.
Abstract
1 Rabbit aorta contracting substance (RCS; consisting mainly of thromboxane A2) and prostaglandin-like material were released from guinea-pig isolated perfused lungs by injection of slow reacting substance of anaphylaxis (SRS-A). 2 SRS-A was resistant to boiling and proteolytic enzymes and was therefore distinguished from rabbit aorta contracting substance releasing factor (RCS-RF). 3 The release of RCS and prostaglandin-like material by SRS-A was anatagonized by indomethacin (1 microgram/ml), betamethasone and dexamethasone (4 to 50 microgram/ml). 4 Imidazole (200 microgram/ml) inhibited the formation of thromboxane A2 but not that of prostaglandins. 5 The activity of SRS-A on guinea-pig ileum and its ability to release RCS and prostaglandins were destroyed by incubation with arylsulphatase (0.83 microgram to 1 mg/ml) and with lipoxidase (16.5 to 50 microgram/ml): SRS-A lost activity on incubation with bovine serum albumin (9 microgram/ml) due to protein binding.
摘要
- 通过注射过敏反应慢反应物质（SRS-A），从豚鼠离体灌注肺中释放出兔主动脉收缩物质（RCS；主要由血栓素A2组成）和类前列腺素物质。2. SRS-A对煮沸和蛋白水解酶具有抗性，因此与兔主动脉收缩物质释放因子（RCS-RF）不同。3. 吲哚美辛（1微克/毫升）、倍他米松和地塞米松（4至50微克/毫升）可拮抗SRS-A引起的RCS和类前列腺素物质的释放。4. 咪唑（200微克/毫升）抑制血栓素A2的形成，但不抑制前列腺素的形成。5. 通过与芳基硫酸酯酶（0.83微克至1毫克/毫升）和脂氧化酶（16.5至50微克/毫升）孵育，SRS-A对豚鼠回肠的活性及其释放RCS和前列腺素的能力被破坏：由于蛋白质结合，SRS-A与牛血清白蛋白（9微克/毫升）孵育后失去活性。
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