Bechgaard E, Ploug E, Hjorth N
Contact Dermatitis. 1985 Aug;13(2):53-5. doi: 10.1111/j.1600-0536.1985.tb02504.x.
In a joint study, 2061 patients (1346 women and 715 men) were patch tested with chlorhexidine gluconate 1% in water, included in a standard test series. 48 patients (2.3%) showed a positive reaction. These were relatively more common in men (3.2%) than in women (1.9%). Positive reactions were most common in patients with leg eczema (6.8%) or leg ulcer (10.9%). Of the 48 patients who were patch test positive, 14 (2 with leg ulcer) were retested with chlorhexidine gluconate 0.01 and 1%. Only one with a leg ulcer was positive. These findings indicate that false positive reactions, known as "the excited skin syndrome", may arise from testing eczema patients in a standard series. The sensitizing potential of chlorhexidine may be very low, but the potential in patients with an eczema or ulcer of the leg has to be further evaluated.
在一项联合研究中，2061名患者（1346名女性和715名男性）用1%葡萄糖酸氯己定水溶液进行斑贴试验，该试验包含在一个标准测试系列中。48名患者（2.3%）出现阳性反应。这些反应在男性（3.2%）中比在女性（1.9%）中相对更常见。阳性反应在腿部湿疹患者（6.8%）或腿部溃疡患者（10.9%）中最为常见。在48名斑贴试验呈阳性的患者中，14名（2名患有腿部溃疡）用0.01%和1%的葡萄糖酸氯己定重新进行测试。只有一名腿部溃疡患者呈阳性。这些发现表明，被称为“皮肤兴奋综合征”的假阳性反应可能源于在标准系列中对湿疹患者进行测试。氯己定的致敏潜力可能非常低，但腿部患有湿疹或溃疡的患者的潜在致敏情况仍需进一步评估。
