Mariello Massimo
Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, OX37DQ, UK.
Bioelectron Med. 2025 Jul 12;11(1):16. doi: 10.1186/s42234-025-00179-4.
Bioelectronic Medicine relies on wearable or implantable electronic devices interfacing with the nervous system and other active tissues, offering innovative therapeutic solutions. However, the long-term reliability and stability of these devices remain critical challenges that must be addressed for widespread clinical adoption. Advances in materials science, device engineering, power management, and biocompatibility are essential to ensure sustained functionality in dynamic biological environments. This perspective highlights key factors affecting the durability, reliability and stability of Bioelectronic Medicine technologies, explores current solutions and emerging approaches, and outlines the necessary steps to achieve robust, long-lasting bioelectronic therapeutics. The personal view expressed in this article is aimed to provide structured, accessible insights that support teaching and learning, and is envisioned to help motivate other investigators to develop further strategies for achieving clinically-relevant ultra-stable bioelectronics.
生物电子医学依赖于与神经系统和其他活性组织连接的可穿戴或植入式电子设备，提供创新的治疗解决方案。然而，这些设备的长期可靠性和稳定性仍然是广泛临床应用必须解决的关键挑战。材料科学、设备工程、电源管理和生物相容性方面的进展对于确保在动态生物环境中的持续功能至关重要。这一观点强调了影响生物电子医学技术耐久性、可靠性和稳定性的关键因素，探讨了当前的解决方案和新兴方法，并概述了实现强大、持久的生物电子治疗所需的步骤。本文所表达的个人观点旨在提供结构化、易懂的见解以支持教学和学习，并期望有助于激励其他研究人员制定进一步的策略来实现与临床相关的超稳定生物电子学。
