Zhang Cheng, Zhang Lirong, Zhao Meiting, Shao Ning, Song Shuo, Zhu Xiaolan
Institute of Advanced Technology, University of Science and Technology of China, Hefei 230031, China.
Research Center of Tobacco and Healthy, University of Science and Technology of China, Hefei 230086, China.
Molecules. 2025 Jun 23;30(13):2698. doi: 10.3390/molecules30132698.
Linalyl acetate (LA), a key volatile component in essential oils, is extensively utilized in fragrance, food, and cosmetic industries. Nevertheless, its practical applications are constrained by rapid evaporation and physicochemical instability. This study developed novel cyclodextrin-metal-organic frameworks (CD-MOFs) crystallized from β-cyclodextrin (β-CD) and γ-cyclodextrin (γ-CD) with potassium hydroxide, demonstrating superior structural properties for LA encapsulation. Through comparative analysis with native CDs, the synthesized CD-MOFs exhibited highly ordered crystalline architectures and uniform morphological characteristics. The LA encapsulation capacity of the γ-CD-MOF was systematically evaluated under different conditions using a three-level factorial design via RSM. Optimization revealed maximum encapsulation efficiency (25.9%) under ideal conditions-an LA:γ-CD-MOF mass ratio of 3.8:1, 60.9 °C incubation temperature, and 49.3 min processing time-representing a 2.39-fold enhancement over conventional CD encapsulation. Thermal stability analysis demonstrated remarkable improvement, with LA-γ-CD-MOF complexes showing an onset decomposition temperature of 215 °C, 135 °C higher than that of free LA. Compared with LA-γ-CD, LA coated with γ-CD-MOFs still retained 55.7% at 80 °C for 75 min, with the release rate reduced by about 45.3%. These findings establish the potential of γ-CD-MOFs as effective carriers for thermolabile and volatile compounds in functional food and cosmetic industries.
乙酸芳樟酯（LA）是香精油中的一种关键挥发性成分，广泛应用于香料、食品和化妆品行业。然而，其实际应用受到快速蒸发和物理化学不稳定性的限制。本研究利用β-环糊精（β-CD）和γ-环糊精（γ-CD）与氢氧化钾结晶制备了新型环糊精-金属有机框架（CD-MOFs），其对LA具有优异的包封结构性能。通过与天然环糊精的对比分析，合成的CD-MOFs呈现出高度有序的晶体结构和均匀的形态特征。采用响应面法（RSM）的三级析因设计，系统评估了γ-CD-MOF在不同条件下对LA的包封能力。优化结果表明，在理想条件下（LA与γ-CD-MOF的质量比为3.8:1、孵育温度为60.9℃、处理时间为49.3分钟），包封效率最高可达25.9%，比传统环糊精包封提高了2.39倍。热稳定性分析表明，LA-γ-CD-MOF配合物的起始分解温度为215℃，比游离LA高135℃，热稳定性显著提高。与LA-γ-CD相比，γ-CD-MOF包被的LA在80℃下75分钟后仍保留55.7%，释放速率降低了约45.3%。这些研究结果证实了γ-CD-MOFs在功能性食品和化妆品行业中作为热敏性和挥发性化合物有效载体的潜力。
