Barnes D W, Sanders V M, White K L, Shopp G M, Munson A E
Drug Chem Toxicol. 1985;8(5):373-92. doi: 10.3109/01480548509041065.
Trans-1,2-dichloroethylene (DCE) was administered to male and female CD-1 mice in order to evaluate its effects on standard toxicological parameters. Following an acute LD50 determination (2122 mg/kg in males and 2391 mg/kg in females) and a 14-day range-finding study, a 90-day drinking water study was performed using levels of DCE calculated to deliver approximately 1/100, 1/10, and 1/5 the LD50. Various toxicological assessments were made, including body and organ weights, hematology, serum chemistries, and hepatic microsomal activities. Few alterations were observed in either sex following 90 days of exposure. The most noteworthy changes occurred in the males exposed to the highest level of DCE, where there was a significant decrease in glutathione levels, and in the females exposed to all three DCE levels, where there was a significant decrease in aniline hydroxylase activity. These data served as background for the immunotoxicological evaluation presented in the following manuscript.
为了评估反式-1,2-二氯乙烯（DCE）对标准毒理学参数的影响，将其给予雄性和雌性CD-1小鼠。在进行急性半数致死剂量（LD50）测定（雄性为2122 mg/kg，雌性为2391 mg/kg）和为期14天的预试验后，开展了一项为期90天的饮用水研究，所使用的DCE水平经计算可提供约为LD50的1/100、1/10和1/5。进行了各种毒理学评估，包括体重和器官重量、血液学、血清化学以及肝微粒体活性。暴露90天后，两性均未观察到明显变化。最值得注意的变化发生在暴露于最高水平DCE的雄性小鼠中，其谷胱甘肽水平显著降低；以及暴露于所有三个DCE水平的雌性小鼠中，其苯胺羟化酶活性显著降低。这些数据为以下手稿中提出的免疫毒理学评估提供了背景。
