Van Tran Vinh, Bui Vu Khac Hoang, Lee Daeho
Laser & Thermal Engineering Lab, Department of Mechanical Engineering, Gachon University, Seongnam 13120, Republic of Korea.
Laboratory for Advanced Nanomaterials and Sustainable Energy Technologies, Institute for Computational Science and Artificial Intelligence, Van Lang University, Ho Chi Minh City, Viet Nam; Faculty of Applied Technology, School of Technology, Van Lang University, Ho Chi Minh City, Viet Nam.
Biosens Bioelectron. 2025 Nov 15;288:117755. doi: 10.1016/j.bios.2025.117755. Epub 2025 Jul 5.
Wearable biosensors and bioelectronics are considered some of the most crucial technologies for the continuous and real-time monitoring of physiological health, clinical diagnosis, and disease biomarkers, offering effective early-stage prevention of human health problems. However, the development and fabrication of these devices have encountered significant challenges owing to the inherent constraints, low efficiency, and limited performance of conventional technologies in preparing, depositing, and stabilizing materials on supporting substrates. Laser material processing (LMP) has emerged as a promising alternative to traditional methods for effectively patterning flexible and stretchable electrodes in biosensors and bioelectronics. This method leverages the unique properties of lasers to enable highly precise, customizable, and rapid prototyping, as well as the versatile construction of novel material structures with outstanding features. By heating or cross-linking the target materials, LMP can be effectively applied to various materials, facilitating the fabrication of compact and multifunctional wearable biosensors through a non-contact, high throughput process. This review consolidates existing scientific evidence on recent advances, development trends, and the applicability of LMP in fabricating wearable biosensors and bioelectronics. It provides a comprehensive overview of the remarkable features, advantages, and underlying principles of LMP, while also addressing the challenges and limitations involved in constructing these wearable devices-ultimately aiming to drive innovation in future research. Additionally, the latest advancements in the use of LMP for fabricating flexible and wearable electrodes with promising materials for high-performance wearable biosensors are also discussed, offering insights into potential future directions.
可穿戴生物传感器和生物电子器件被认为是用于持续实时监测生理健康、临床诊断和疾病生物标志物的一些最关键技术，可有效实现人类健康问题的早期预防。然而，由于传统技术在支撑基板上制备、沉积和稳定材料时存在固有局限性、效率低下和性能有限等问题，这些器件的开发和制造面临着重大挑战。激光材料加工（LMP）已成为一种有前景的替代传统方法，可用于在生物传感器和生物电子器件中有效地对柔性和可拉伸电极进行图案化。该方法利用激光的独特特性实现高精度、可定制和快速原型制作，以及构建具有出色特性的新型材料结构。通过加热或交联目标材料，LMP可有效地应用于各种材料，通过非接触、高通量工艺促进紧凑型和多功能可穿戴生物传感器的制造。本综述整合了关于LMP在制造可穿戴生物传感器和生物电子器件方面的最新进展、发展趋势和适用性的现有科学证据。它全面概述了LMP的显著特征、优势和基本原理，同时也解决了构建这些可穿戴设备所涉及的挑战和局限性，最终目标是推动未来研究的创新。此外，还讨论了使用LMP制造具有用于高性能可穿戴生物传感器的有前景材料的柔性和可穿戴电极的最新进展，为潜在的未来方向提供了见解。
