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地理、基因与病菌:一种进化上的纠葛。

Geography, genes, and germs: An evolutionary entanglement.

作者信息

Kattner Aila Akosua

出版信息

Biomed J. 2025 Jul 10;48(4):100888. doi: 10.1016/j.bj.2025.100888.

DOI:10.1016/j.bj.2025.100888
PMID:40651609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12337660/
Abstract

This journal issue presents an article on genomic surveillance and phylogenetic analysis for monitoring SARS-CoV-2, alongside reviews of recent advances in the treatment of hepatocellular carcinoma and gastric cancer, and current insights into mpox. It includes a perspective on the role of extended reality techniques in pediatric neurosurgery, as well as updates on cleft care and the relationship between mitochondrial bioenergetics and iron. Further contributions explore the link between metastatic potential and cytidine deaminase, miRNA targets involved in hypertrophy and fibrosis during cardiac remodeling, and new deep-learning models for predicting response to cardiac resynchronization therapy. The expression of connexin gap junction proteins in atrial fibrillation is examined in detail, along with a retrospective study on enteral autonomy in pediatric short bowel syndrome. The issue concludes with novel insights into the rare genetic disorder Bietti crystalline dystrophy.

摘要

本期杂志发表了一篇关于监测严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的基因组监测和系统发育分析的文章,同时还有关于肝细胞癌和胃癌治疗最新进展以及当前猴痘见解的综述。它包括对扩展现实技术在小儿神经外科中作用的展望,以及腭裂护理的最新情况和线粒体生物能量学与铁之间的关系。进一步的文章探讨了转移潜能与胞苷脱氨酶之间的联系、心脏重塑过程中涉及肥大和纤维化的微小RNA(miRNA)靶点,以及预测心脏再同步治疗反应的新深度学习模型。详细研究了连接蛋白缝隙连接蛋白在心房颤动中的表达,以及一项关于小儿短肠综合征肠自主功能的回顾性研究。本期以对罕见遗传病比埃蒂结晶状营养不良的新见解作为结尾。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af5/12337660/3377704ed50a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af5/12337660/3377704ed50a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af5/12337660/3377704ed50a/gr1.jpg

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本文引用的文献

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An Overview of Monkey Pox Disease as a Current Important Disease in the World.猴痘病概述——当今世界一种重要疾病
Arch Razi Inst. 2024 Dec 31;79(6):1121-1133. doi: 10.32592/ARI.2024.79.6.1121. eCollection 2024 Dec.
2
IRE1α-mediated endoplasmic reticulum stress response regulates oxidative damage in CYP4V2 deficient human retinal pigment epithelial cells.IRE1α介导的内质网应激反应调节CYP4V2缺陷型人视网膜色素上皮细胞中的氧化损伤。
Biomed J. 2025 Aug;48(4):100875. doi: 10.1016/j.bj.2025.100875. Epub 2025 Jun 2.
3
Intestinal autonomy in extreme premature infants with short bowel syndrome: national experience.
极早早产儿短肠综合征的肠道自主性:国家经验
Pediatr Surg Int. 2025 May 24;41(1):143. doi: 10.1007/s00383-025-06036-4.
4
The essence of cleft care: From embryogenesis to surgical management.腭裂护理的精髓:从胚胎发育到手术治疗
Biomed J. 2025 Aug;48(4):100825. doi: 10.1016/j.bj.2024.100825. Epub 2024 Dec 16.
5
Mpox: A narrative review on current knowledge.猴痘:关于当前知识的叙述性综述
Biomed J. 2024 Dec 15;48(4):100823. doi: 10.1016/j.bj.2024.100823.
6
Application of extended reality in pediatric neurosurgery: A comprehensive review.扩展现实在小儿神经外科中的应用:一项综述
Biomed J. 2024 Dec 8;48(4):100822. doi: 10.1016/j.bj.2024.100822.
7
Genomic Surveillance of SARS-CoV-2 in Taiwan: A Perspective on Evolutionary Data Interpretation and Sequencing Issues.台湾地区严重急性呼吸综合征冠状病毒2的基因组监测:进化数据解读与测序问题的视角
Biomed J. 2024 Nov 26:100820. doi: 10.1016/j.bj.2024.100820.
8
Endothelial activation, cell-cell interactions, and inflammatory pathways in postoperative atrial fibrillation following cardiac surgery.心脏手术后房颤中的内皮激活、细胞间相互作用及炎症途径。
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