Ahmad Jamil Hajar, Abdul Karim Norwahidah
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Biomed Pharmacother. 2025 Aug;189:118349. doi: 10.1016/j.biopha.2025.118349. Epub 2025 Jul 12.
Mitochondria play a vital impact in maintaining the well-being of the skin, by regulating key cellular activities and processes in various skin cell types, including keratinocytes, fibroblasts, and melanocytes. Understanding their activity and dysfunction is essential for comprehending the pathophysiology of skin diseases and establishing viable therapeutic approaches. This review synthesizes current knowledge on the role of mitochondria in skin cells and their impact on disease progression. In keratinocytes, mitochondria support differentiation and skin barrier formation. In fibroblasts, they are essential for collagen synthesis and maintaining redox balance. In melanocytes, mitochondria facilitate melanin synthesis and protect against UV-induced oxidative damage. Mitochondrial dysfunction, characterized by generation of reactive oxygen species (ROS), alterations in mitochondrial DNA (mtDNA), and changes in biogenesis and dynamics, has been linked to skin diseases such as psoriasis, atopic dermatitis, and vitiligo. These dysfunctions disrupt cellular energy metabolism and stress responses, compromising skin structure and function. Mitochondria are therefore integral not only to energy production and oxidative stress regulation but also to the overall biosynthetic and protective functions of the skin. Future research should aim to deepen our understanding of mitochondrial dysfunction in skin cells and explore targeted strategies to restore mitochondrial health in skin diseases.
线粒体通过调节包括角质形成细胞、成纤维细胞和黑素细胞在内的各种皮肤细胞类型中的关键细胞活动和过程，对维持皮肤健康起着至关重要的作用。了解它们的活性和功能障碍对于理解皮肤疾病的病理生理学以及建立可行的治疗方法至关重要。本综述综合了关于线粒体在皮肤细胞中的作用及其对疾病进展影响的现有知识。在角质形成细胞中，线粒体支持分化和皮肤屏障形成。在成纤维细胞中，它们对于胶原蛋白合成和维持氧化还原平衡至关重要。在黑素细胞中，线粒体促进黑色素合成并抵御紫外线诱导的氧化损伤。线粒体功能障碍以活性氧（ROS）生成、线粒体DNA（mtDNA）改变以及生物发生和动力学变化为特征，与银屑病、特应性皮炎和白癜风等皮肤疾病有关。这些功能障碍破坏细胞能量代谢和应激反应，损害皮肤结构和功能。因此，线粒体不仅对于能量产生和氧化应激调节不可或缺，而且对于皮肤的整体生物合成和保护功能也不可或缺。未来的研究应旨在加深我们对皮肤细胞中线粒体功能障碍的理解，并探索在皮肤疾病中恢复线粒体健康的靶向策略。
