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霍乱弧菌非01型产生的热稳定肠毒素的氨基酸序列

Amino acid sequence of heat-stable enterotoxin produced by Vibrio cholerae non-01.

作者信息

Takao T, Shimonishi Y, Kobayashi M, Nishimura O, Arita M, Takeda T, Honda T, Miwatani T

出版信息

FEBS Lett. 1985 Dec 2;193(2):250-4. doi: 10.1016/0014-5793(85)80163-0.

DOI:10.1016/0014-5793(85)80163-0
PMID:4065341
Abstract

The amino acid sequence of heat-stable enterotoxin, produced by Vibrio cholerae non-01 and isolated from its culture supernatant, was determined by both Edman degradation of native and reductively carboxymethylated enterotoxin and also a combination of fast atom bombardment mass spectrometry and carboxypeptidase Y digestion of native enterotoxin to be as follows: Ile-Asp-Cys-Cys-Glu-Ile-Cys-Cys-Asn-Pro-Ala-Cys-Phe-Gly-Cys-Leu-Asn. This sequence is very similar, but not identical, to those of heat-stable enterotoxins produced by enterotoxigenic Escherichia coli and Yersinia enterocolitica.

摘要

从霍乱弧菌非01群培养上清液中分离出的热稳定肠毒素的氨基酸序列，通过对天然及还原羧甲基化肠毒素进行埃德曼降解，以及结合快速原子轰击质谱法和对天然肠毒素进行羧肽酶Y消化来确定，结果如下：异亮氨酸-天冬氨酸-半胱氨酸-半胱氨酸-谷氨酸-异亮氨酸-半胱氨酸-半胱氨酸-天冬酰胺-脯氨酸-丙氨酸-半胱氨酸-苯丙氨酸-甘氨酸-半胱氨酸-亮氨酸-天冬酰胺。该序列与产肠毒素大肠杆菌和小肠结肠炎耶尔森菌产生的热稳定肠毒素的序列非常相似，但并不相同。

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