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作为牙科生物材料的纤维素纳米纤维的机械性能和生物学性能

Mechanical and biological properties of cellulose nanofibers as a dental biomaterial.

作者信息

Chen Junduo, Ma Aobo, Zhang Yiding, Sun Lu, Yang Kunhua, Vanegas Sáenz Juan Ramón, Hong Guang

机构信息

Division for Globalization Initiative, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Department of Periodontology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.

出版信息

J Dent Sci. 2025 Jul;20(3):1436-1446. doi: 10.1016/j.jds.2025.02.006. Epub 2025 Feb 18.

DOI:10.1016/j.jds.2025.02.006
PMID:40654476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12254768/
Abstract

BACKGROUND/PURPOSE: Plant-derived cellulose nanofibers (CNF) have emerged as a promising material for biomedical applications due to their diverse and exceptional properties but application in dental research remains limited. This study aimed to use CNF as barrier membranes or scaffold materials applied in guided bone regeneration (GBR) and guided tissue regeneration (GTR).

MATERIALS AND METHODS

Two different thicknesses of CNF were detected by surface morphology, roughness, hydrophilicity, mechanical properties, and degradability test, and compared with GC Membrane and Ti (titanium). Additionally, the cell compatibility and cell morphology of MC3T3-E1 and HGF-1 in different groups were also studied. The alkaline phosphatase (ALP) activity of MC3T3-E1 was also examined on the 14th and 21st days.

RESULTS

Compared to the GC membrane, CNF showed better mechanical properties but remained inferior to titanium. Soaking increased their roughness and hydrophilicity while reducing mechanical strength. CNF also exhibited degradability, and good biocompatibility, with ALP expression significantly elevated at 14 and 21 days.

CONCLUSION

The results of this study on various properties of CNF indicate that CNF has the potential to become a novel dental biomaterial.

摘要

背景/目的：植物源纤维素纳米纤维（CNF）因其多样且独特的性能，已成为生物医学应用中有前景的材料，但在牙科研究中的应用仍然有限。本研究旨在将CNF用作引导骨再生（GBR）和引导组织再生（GTR）中应用的屏障膜或支架材料。

材料与方法

通过表面形态、粗糙度、亲水性、力学性能和降解性测试检测两种不同厚度的CNF，并与GC膜和钛（Ti）进行比较。此外，还研究了不同组中MC3T3-E1和HGF-1的细胞相容性和细胞形态。在第14天和第21天还检测了MC3T3-E1的碱性磷酸酶（ALP）活性。

结果

与GC膜相比，CNF表现出更好的力学性能，但仍不如钛。浸泡会增加其粗糙度和亲水性，同时降低机械强度。CNF还表现出降解性和良好的生物相容性，在第14天和第21天碱性磷酸酶表达显著升高。

结论

本研究对CNF各种性能的结果表明，CNF有潜力成为一种新型牙科生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e888fb0c70de/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/dc70f2e552bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e27f038fd5a9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/6688fc24b1e9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/f13892374a4c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/1ea24b694940/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e1c4297baa21/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/8bb87877e79d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/848099349b0d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/969b43b460e6/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e888fb0c70de/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/dc70f2e552bd/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e27f038fd5a9/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/6688fc24b1e9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/f13892374a4c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/1ea24b694940/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e1c4297baa21/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/8bb87877e79d/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/848099349b0d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/969b43b460e6/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f78/12254768/e888fb0c70de/gr10.jpg

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