Chen Xiangrui, Hu Min, Hao Chengluo, Li Jun, Han Yunwei
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Oncology, Third People's Hospital of Zigong, Zigong, China.
Front Nutr. 2025 Jun 27;12:1587824. doi: 10.3389/fnut.2025.1587824. eCollection 2025.
This study aimed to investigate the combined predictive value of the Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI) for all-cause mortality in cancer survivors.
Using NHANES data (1999-2018), 2,969 eligible cancer survivors were categorized into four groups based on SII and GNRI levels. Mortality risk was assessed through unadjusted and fully adjusted Cox proportional hazards models.
The combination of low SII and high GNRI was associated with the lowest mortality risk (HR = 1.0, reference). In contrast, high SII and low GNRI significantly increased mortality risk (fully adjusted HR = 6.178, 95% CI: 2.669-14.299). Both unadjusted and adjusted models confirmed that high SII correlated with higher mortality, while low GNRI independently predicted poorer outcomes. Subgroup analyses revealed significant interactions between the SII-GNRI combination and gender/alcohol consumption.
The findings highlight SII and GNRI as critical predictors of all-cause mortality in cancer survivors. Their combined assessment may improve risk stratification and guide targeted clinical interventions.
本研究旨在探讨全身免疫炎症指数（SII）和老年营养风险指数（GNRI）对癌症幸存者全因死亡率的联合预测价值。
利用美国国家健康与营养检查调查（NHANES）数据（1999 - 2018年），根据SII和GNRI水平将2969名符合条件的癌症幸存者分为四组。通过未调整和完全调整的Cox比例风险模型评估死亡风险。
低SII和高GNRI的组合与最低死亡风险相关（风险比[HR]=1.0，参照组）。相比之下，高SII和低GNRI显著增加死亡风险（完全调整后的HR = 6.178，95%置信区间[CI]：2.669 - 14.299）。未调整和调整后的模型均证实，高SII与较高死亡率相关，而低GNRI独立预测较差的预后。亚组分析显示SII - GNRI组合与性别/饮酒之间存在显著交互作用。
研究结果突出了SII和GNRI作为癌症幸存者全因死亡率关键预测指标的作用。它们的联合评估可能改善风险分层并指导针对性的临床干预。
