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Recent developments in human cell models in mental disorders.

作者信息

Kittel-Schneider Sarah

机构信息

Department of Psychiatry and Neurobehavioural Science, University College Cork, Acute Adult Mental Health Unit, Cork University Hospital, T12DC4A, Wilton, Cork, Ireland.

出版信息

Neurosci Appl. 2024 Jan 11;3:103939. doi: 10.1016/j.nsa.2024.103939. eCollection 2024.

DOI:10.1016/j.nsa.2024.103939
PMID:40656080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12244035/
Abstract
摘要

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Power and optimal study design in iPSC-based brain disease modelling.基于 iPSC 的脑疾病建模中的效能和最佳研究设计。
Mol Psychiatry. 2023 Apr;28(4):1545-1556. doi: 10.1038/s41380-022-01866-3. Epub 2022 Nov 16.
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A Common Variant Is Associated with Low Agreeableness and Neural Responses to Working Memory Tasks in ADHD.一种常见变异与 ADHD 患者的低宜人性和工作记忆任务的神经反应有关。
Genes (Basel). 2021 Aug 29;12(9):1356. doi: 10.3390/genes12091356.
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Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.钙黏蛋白 13 是人类干细胞源性神经元网络中 GABA 能调制的关键调节因子。
Mol Psychiatry. 2022 Jan;27(1):1-18. doi: 10.1038/s41380-021-01117-x. Epub 2021 May 10.
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Challenges of Psychiatry Drug Development and the Role of Human Pharmacology Models in Early Development-A Drug Developer's Perspective.精神药理学药物研发的挑战以及人体药理学模型在早期研发中的作用——来自药物研发者的视角
Front Psychiatry. 2021 Jan 27;11:562660. doi: 10.3389/fpsyt.2020.562660. eCollection 2020.
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Transl Psychiatry. 2020 Sep 18;10(1):315. doi: 10.1038/s41398-020-00999-9.
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ADHD and depression: investigating a causal explanation.注意缺陷多动障碍与抑郁：探究因果关系。
Psychol Med. 2021 Aug;51(11):1890-1897. doi: 10.1017/S0033291720000665. Epub 2020 Apr 6.
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Risk Factors for Depression in Adolescents With ADHD: The Impact of Cognitive Biases and Stress.注意缺陷多动障碍青少年抑郁的风险因素：认知偏差和压力的影响。
J Atten Disord. 2021 Feb;25(3):340-354. doi: 10.1177/1087054718797447. Epub 2018 Sep 10.
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Methylphenidate enhances neuronal differentiation and reduces proliferation concomitant to activation of Wnt signal transduction pathways.哌醋甲酯增强神经元分化，同时减少增殖，伴随 Wnt 信号转导途径的激活。
Transl Psychiatry. 2018 Mar 1;8(1):51. doi: 10.1038/s41398-018-0096-8.
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Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling.氯胺酮通过 AMPAR 驱动的 BDNF 和 mTOR 信号增强小鼠中脑和人诱导多能干细胞源性多巴胺能神经元的结构可塑性。
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