Khalid Subhan, Hitch Alan T
Harrisburg University of Science and Technology.
J Health Econ Outcomes Res. 2025 Jul 9;12(2):1-10. doi: 10.36469/001c.141171. eCollection 2025.
Patients with hereditary angioedema treated with fresh frozen plasma (FFP) infusion face complications and risk of side effects. To study the effect of FFP infusion on hospital length of stay for patients with hereditary angioedema. Data from the 2021 Nationwide Inpatient Sample were used to identify hospitalized patients with hereditary angioedema. Patient demographics, comorbidities, and severity measures were analyzed, and a Bayesian additive regression tree model was used to assess factors contributing to length of stay. FFP infusion was found to be associated with increased length of stay for patients with risk factors such as respiratory, cardiovascular disease, or urticaria. Caution is recommended when planning to use FFP, to ensure that underlying patient conditions and risk factors are thoroughly understood. The findings emphasize the need for personalized treatment plans based on individual risk factors, with a recommendation for prioritizing C1-inhibitor therapy over FFP.
接受新鲜冷冻血浆（FFP）输注治疗的遗传性血管性水肿患者面临并发症和副作用风险。为研究FFP输注对遗传性血管性水肿患者住院时间的影响。利用2021年全国住院患者样本数据来识别住院的遗传性血管性水肿患者。分析了患者的人口统计学特征、合并症和严重程度指标，并使用贝叶斯加法回归树模型评估影响住院时间的因素。结果发现，对于患有呼吸、心血管疾病或荨麻疹等风险因素的患者，FFP输注与住院时间延长有关。建议在计划使用FFP时谨慎行事，以确保充分了解患者的潜在病情和风险因素。研究结果强调了基于个体风险因素制定个性化治疗方案的必要性，并建议优先采用C1抑制剂治疗而非FFP。
