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芹菜提取物通过激活Nrf2抗氧化信号通路减轻庆大霉素长期给药诱导的小鼠肝肾损伤。

Extracts of (Celery) attenuate hepato-renal injury induced by chronic administration of gentamicin in mice through activation of Nrf2-antioxidant signaling pathways.

作者信息

Kouam Arnaud Fondjo, Mokam Mayelle Mepa, Ngounou Eleonore, Kouoh Ferdinand Elombo, Fifen Rodrigue, Kongnyuy Kerinyuy Juliene, Zeuko'o Elisabeth Menkem, Nembo Nembu Erastus, Djamen Pascal Dieudonné Chuisseu, Njayou Frédéric Nico, Moundipa Paul Fewou, Asongalem Emmanuel Acha

机构信息

Medical Research and Applied Biochemistry Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon.

Pharmacology Laboratory, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, PO Box 63, Buea, Cameroon.

出版信息

Avicenna J Phytomed. 2025 Jul-Aug;15(4):1341-1357. doi: 10.22038/ajp.2024.25338.

DOI:10.22038/ajp.2024.25338
PMID:40656623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12244956/
Abstract

OBJECTIVE

This study aimed at investigating the protective effect of extracts from  against gentamicin-induced hepato-renal toxicity.

MATERIALS AND METHODS

The aqueous and hydro-ethanolic extracts of  designated respectively as WAG and HAG were tested for their antioxidant activities. Then, their cytoprotective effects were assessed against gentamicin-induced cytotoxicity in primary mouse hepatocytes. Finally, mice were administered with gentamicin (20 mg/kg) and co-treated with HAG for 14 days, and histopathology, biochemical and molecular parameters related to gentamicin-induced toxicity were evaluated.

RESULTS

HAG exhibited outstanding chemical antioxidant activities and preserved hepatocytes from gentamicin-induced cytotoxicity. HAG relieved liver and kidney histopathological and biochemical changes, and enhanced the mRNA level of Nrf2 and its target gene HO-1 in gentamicin-intoxicated mice.

CONCLUSION

HAG attenuates hepato-renal injuries induced by 14-days administration of gentamicin in mice through the activation of Nrf2-antioxidant signaling pathways.

摘要

目的

本研究旨在探讨[未提及植物名称]提取物对庆大霉素诱导的肝肾毒性的保护作用。

材料与方法

分别测定了[未提及植物名称]的水提取物和水乙醇提取物（分别命名为WAG和HAG）的抗氧化活性。然后，评估它们对原代小鼠肝细胞中庆大霉素诱导的细胞毒性的细胞保护作用。最后，给小鼠注射庆大霉素（20 mg/kg）并与HAG共同处理14天，评估与庆大霉素诱导的毒性相关的组织病理学、生化和分子参数。

结果

HAG表现出出色的化学抗氧化活性，并保护肝细胞免受庆大霉素诱导的细胞毒性。HAG减轻了肝肾组织病理学和生化变化，并提高了庆大霉素中毒小鼠中Nrf2及其靶基因HO-1的mRNA水平。

结论

HAG通过激活Nrf2抗氧化信号通路减轻了小鼠14天给予庆大霉素所诱导的肝肾损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/7fbba4bf794d/AJP-15-1341-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/e15c76c80565/AJP-15-1341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/5b8fe6fa55ad/AJP-15-1341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/cd83a6e52570/AJP-15-1341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/e720d2abfa5b/AJP-15-1341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/dfb76c3932ac/AJP-15-1341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/c9738ececed1/AJP-15-1341-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/7fbba4bf794d/AJP-15-1341-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/e15c76c80565/AJP-15-1341-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/5b8fe6fa55ad/AJP-15-1341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/cd83a6e52570/AJP-15-1341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/e720d2abfa5b/AJP-15-1341-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/dfb76c3932ac/AJP-15-1341-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/c9738ececed1/AJP-15-1341-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2059/12244956/7fbba4bf794d/AJP-15-1341-g007.jpg

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