Kooti Wesam, Moradi Maryam, Peyro Khadijeh, Sharghi Maedeh, Alamiri Fatima, Azami Milad, Firoozbakht Mohammad, Ghafourian Mehri
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Department of Biology, School of Science, Shahid Chamran University, Ahvaz, Iran.
J Complement Integr Med. 2017 Oct 6;15(2):/j/jcim.2018.15.issue-2/jcim-2016-0141/jcim-2016-0141.xml. doi: 10.1515/jcim-2016-0141.
Background Fertility and infertility problems are among the complex issues in medicine. The use of herbal products in the treatment of fertility has been considered as an alternative to synthetic drugs. Celery containing known compounds can have an impact on the fertility rate. The aim of this study was to do a systematic review on conducted studies in conjunction with the celery and reproduction. Methods Required papers were searched from databases like Science direct, PubMed, Scopus, and Springer. Keywords used in this study were "Apium graveolens L.", "fertility", "reproductive system", "sperm", "testis", "delivery", "sexual hormone", "LH", "FSH", "testosterone", "semen", "male", and "female". Out of 238 collected articles (published in the period 1995 to 2015), 222 were excluded due to non-relevance and lack of access to the original article. Results The notable points were the different results seen by different researchers during different treatment periods or at different doses. Of the 16 studies reviewed in this study, 13 studies have mentioned the positive effect of celery on fertility, while three studies reported the inhibitory effects of this plant. Conclusions Celery can have protective effects against substances such as sodium valproate, propylene glycol, and diethyl phthalate causing damages to the testicular structure and spermatogenesis. In this regard, the doses used and the treatment time while using the plant must be accurately investigated. Since there are compounds such as apigenin, the celery can induce inhibitory effects on fertility in case of chronic use or high concentration.
背景 生育和不孕问题是医学领域的复杂问题之一。使用草药产品治疗生育问题已被视为合成药物的一种替代方法。含有已知化合物的芹菜可能会对生育率产生影响。本研究的目的是对已开展的关于芹菜与生殖的研究进行系统综述。方法 从科学Direct、PubMed、Scopus和Springer等数据库中搜索所需论文。本研究使用的关键词有“芹菜”、“生育能力”、“生殖系统”、“精子”、“睾丸”、“分娩”、“性激素”、“促黄体生成素”、“促卵泡生成素”、“睾酮”、“精液”、“男性”和“女性”。在收集的238篇文章（发表于1995年至2015年期间）中，由于不相关和无法获取原始文章，排除了222篇。结果 值得注意的是，不同研究人员在不同治疗时期或不同剂量下得到了不同的结果。在本研究综述的16项研究中，13项研究提到了芹菜对生育能力的积极作用，而3项研究报告了这种植物的抑制作用。结论 芹菜对丙戊酸钠、丙二醇和邻苯二甲酸二乙酯等对睾丸结构和精子发生有损害的物质具有保护作用。在这方面，使用该植物时的剂量和治疗时间必须进行准确研究。由于存在芹菜素等化合物，长期使用或高浓度使用芹菜可能会对生育能力产生抑制作用。
