1990年至2019年尼泊尔孕产妇和新生儿疾病负担：全球疾病负担研究数据分析——一项观察性研究

Burden of Maternal and Neonatal Disorser in Nepal from 1990 to 2019; Analysis of Data from Global Burden of Disease Study: An Observational Study.

作者信息

Rai Pramila, Ackerman Ilana N, O'Connor Denise A, Dangal Ganesh, Buchbinder Rachelle

机构信息

School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Kathmandu Model Hospital, Exhbition Road, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2025 Mar;63(283):134-143. doi: 10.31729/jnma.8916. Epub 2025 Mar 31.

DOI:10.31729/jnma.8916

PMID:40656920

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12122270/

Abstract

INTRODUCTION

Nepal continues to face significant challenges with high maternal and neonatal mortality. To improve health and achieve the Sustainable Development Goals of reducing maternal and newborn mortality by 2030, Nepal needs to focus on addressing high-burden maternal and neonatal disorders. The objective of the study was to examine the current burden of maternal and neonatal disorders in Nepal and to assess any changes over time.

METHODS

We examined the annual Global Burden of Disease Study data on prevalence, deaths, Years Lived with Disability, and Disability-Adjusted Life Years for maternal and neonatal disorders in Nepal for the 1990-2019 period. Estimated annual percentage changes were also calculated to assess the trends of the age-standardised rates of these burden metrics.

RESULTS

The analysis found that the prevalence of overall maternal disorder in Nepal decreased by 37% from 128,176 in 1990 to 80,724 in 2019 with Age-Standarised Ratio of 432.07 per 100,000 in 2019 and Estimated Annual Percentange Change of -4.34 (CI 95%: -4.49 to -4.18). Similarly, the overall prevalence of neonatal disorder increased by 57% from 303,146 in 1990 to 475,544 in 2019 with Age-Standarised Ratio of 1521.14 per 100,000 in 2019 and Estimated Annual Percentage Change of 0.98 (95% CI: 0.67-1.29).

CONCLUSIONS

Our findings emphasise the need to address maternal haemorrhage, indirect maternal deaths, maternal abortion and neonatal disorders in Nepal in future national health programs.

摘要

引言

尼泊尔在孕产妇和新生儿高死亡率方面仍面临重大挑战。为改善健康状况并实现到2030年降低孕产妇和新生儿死亡率的可持续发展目标，尼泊尔需要专注于解决高负担的孕产妇和新生儿疾病。本研究的目的是调查尼泊尔目前孕产妇和新生儿疾病的负担，并评估随时间的任何变化。

方法

我们研究了1990 - 2019年期间尼泊尔孕产妇和新生儿疾病的年度全球疾病负担研究数据，包括患病率、死亡人数、伤残调整生命年和伤残调整生命年。还计算了估计的年度百分比变化，以评估这些负担指标的年龄标准化率趋势。

结果

分析发现，尼泊尔总体孕产妇疾病患病率从1990年的128,176例下降了37%，至2019年为80,724例，2C019年年龄标准化率为每100,000人432.07例，估计年度百分比变化为 - 4.34（95%置信区间： - 4.49至 - 4.18）。同样，新生儿疾病总体患病率从1990年的303,146例增加了57%，至2019年为475,544例，2019年年龄标准化率为每100,000人1521.14例，估计年度百分比变化为0.98（95%置信区间：0.67 - 1.29）。