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诊断难题病例:两种人畜共患病共存

Diagnostically Challenging Case: Coexistence of Two Zoonoses.

作者信息

Törüyenler-Coşkunpınar Melike, Akdemir İrem, Yüksel Seher, Aras Nermin, Kurt-Yüksel Meltem, Azap Alpay

机构信息

Department of Infectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Türkiye.

Department of Pathology, Ankara University School of Medicine, Ankara, Türkiye.

出版信息

Infect Dis Clin Microbiol. 2025 Jun 26;7(2):214-219. doi: 10.36519/idcm.2025.501. eCollection 2025 Jun.

Abstract

A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. amastigotes were seen in the second bone marrow biopsy preparations. PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.

摘要

一名男性患者出现发热、血细胞减少和肝脾肿大。患者的试管凝集试验滴度为1:640时呈阳性。由于对布鲁氏菌病治疗无反应,遂进行了额外检查。在第二次骨髓活检标本中发现了无鞭毛体。聚合酶链反应(PCR)呈阳性,诊断为内脏利什曼病(VL)。在此,我们报告一例VL与布鲁氏菌病合并感染的病例,该病例表现为B症状(发热、盗汗和体重减轻)和血细胞减少,难以诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/539c7184995e/IDCM-7-2-501-figure1.jpg

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