• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

诊断难题病例：两种人畜共患病共存

Diagnostically Challenging Case: Coexistence of Two Zoonoses.

作者信息

Törüyenler-Coşkunpınar Melike, Akdemir İrem, Yüksel Seher, Aras Nermin, Kurt-Yüksel Meltem, Azap Alpay

机构信息

Department of Infectious Diseases and Clinical Microbiology, Ankara University School of Medicine, Ankara, Türkiye.

Department of Pathology, Ankara University School of Medicine, Ankara, Türkiye.

出版信息

Infect Dis Clin Microbiol. 2025 Jun 26;7(2):214-219. doi: 10.36519/idcm.2025.501. eCollection 2025 Jun.

DOI:10.36519/idcm.2025.501
PMID:40657022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12255313/
Abstract

A male patient presented with fever, cytopenia, and hepatosplenomegaly. The patient's tube agglutination test was positive at titers 1:640. Due to the lack of response to brucellosis treatment, additional tests were performed. amastigotes were seen in the second bone marrow biopsy preparations. PCR was positive, and visceral leishmaniasis (VL) was diagnosed. Here, we present a case of VL and brucellosis coinfection that presented with B symptoms (fever, night sweats, and weight loss) and cytopenia and was difficult to diagnose.

摘要

一名男性患者出现发热、血细胞减少和肝脾肿大。患者的试管凝集试验滴度为1:640时呈阳性。由于对布鲁氏菌病治疗无反应，遂进行了额外检查。在第二次骨髓活检标本中发现了无鞭毛体。聚合酶链反应（PCR）呈阳性，诊断为内脏利什曼病（VL）。在此，我们报告一例VL与布鲁氏菌病合并感染的病例，该病例表现为B症状（发热、盗汗和体重减轻）和血细胞减少，难以诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/e793b815c896/IDCM-7-2-501-figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/539c7184995e/IDCM-7-2-501-figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/e793b815c896/IDCM-7-2-501-figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/539c7184995e/IDCM-7-2-501-figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c386/12255313/e793b815c896/IDCM-7-2-501-figure2.jpg

相似文献

1
Diagnostically Challenging Case: Coexistence of Two Zoonoses.诊断难题病例：两种人畜共患病共存
Infect Dis Clin Microbiol. 2025 Jun 26;7(2):214-219. doi: 10.36519/idcm.2025.501. eCollection 2025 Jun.
2
Interventions for Old World cutaneous leishmaniasis.旧世界皮肤利什曼病的干预措施。
Cochrane Database Syst Rev. 2017 Dec 1;12(12):CD005067. doi: 10.1002/14651858.CD005067.pub5.
3
Interventions for Old World cutaneous leishmaniasis.旧世界皮肤利什曼病的干预措施。
Cochrane Database Syst Rev. 2017 Nov 17;11(11):CD005067. doi: 10.1002/14651858.CD005067.pub4.
4
Prevalence of Leishmania infection in refugee camps: A serological and molecular study in Gambella and Benishangul-Gumuz, Ethiopia.难民营中利什曼原虫感染的患病率：埃塞俄比亚甘贝拉和本尚古勒-古穆兹的血清学和分子研究
PLoS Negl Trop Dis. 2025 Jul 8;19(7):e0013280. doi: 10.1371/journal.pntd.0013280. eCollection 2025 Jul.
5
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.
6
Vertical transmission of Leishmania donovani with placental degeneration in the pregnant mouse model of visceral leishmaniasis.在内脏利什曼病的孕鼠模型中，杜氏利什曼原虫的垂直传播与胎盘变性
PLoS Negl Trop Dis. 2025 Jun 9;19(6):e0012650. doi: 10.1371/journal.pntd.0012650. eCollection 2025 Jun.
7
Visceral leishmaniasis mimicking systemic lupus erythematosus: Case series and a systematic literature review.酷似系统性红斑狼疮的内脏利什曼病：病例系列及系统文献综述
Semin Arthritis Rheum. 2015 Jun;44(6):658-65. doi: 10.1016/j.semarthrit.2014.12.004. Epub 2014 Dec 29.
8
Pharmacotherapies for sleep disturbances in dementia.痴呆症睡眠障碍的药物治疗
Cochrane Database Syst Rev. 2016 Nov 16;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub3.
9
Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people.老年人即将发生和当前失水脱水的识别的临床症状、体征及检查
Cochrane Database Syst Rev. 2015 Apr 30;2015(4):CD009647. doi: 10.1002/14651858.CD009647.pub2.
10
Rapid diagnostic tests for typhoid and paratyphoid (enteric) fever.伤寒和副伤寒（肠道）热的快速诊断检测
Cochrane Database Syst Rev. 2017 May 26;5(5):CD008892. doi: 10.1002/14651858.CD008892.pub2.

本文引用的文献

1
The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries.土耳其、阿塞拜疆和格鲁吉亚的利什曼病当前流行病学情况及其对欧洲国家疾病出现的影响。
Zoonoses Public Health. 2022 Aug;69(5):395-407. doi: 10.1111/zph.12977. Epub 2022 May 26.
2
A Review of Leishmaniasis: Current Knowledge and Future Directions.利什曼病综述：当前认知与未来方向
Curr Trop Med Rep. 2021;8(2):121-132. doi: 10.1007/s40475-021-00232-7. Epub 2021 Mar 17.
3
Case Report: Visceral Leishmaniasis with Paratyphi and Coinfection as a Cause of Persistent Fever in a Patient from Sudan.
病例报告：来自苏丹的患者持续性发热，原因是内脏利什曼病合并副伤寒和合并感染。
Am J Trop Med Hyg. 2018 Nov;99(5):1150-1152. doi: 10.4269/ajtmh.18-0466.
4
Leishmaniasis.利什曼病。
Lancet. 2018 Sep 15;392(10151):951-970. doi: 10.1016/S0140-6736(18)31204-2. Epub 2018 Aug 17.
5
Leishmaniasis in Turkey: Visceral and cutaneous leishmaniasis caused by Leishmania donovani in Turkey.土耳其的利什曼病：土耳其由杜氏利什曼原虫引起的内脏利什曼病和皮肤利什曼病。
Acta Trop. 2017 Sep;173:90-96. doi: 10.1016/j.actatropica.2017.05.032. Epub 2017 Jun 3.
6
Innovative modifications to Rose Bengal plate test enhance its specificity, sensitivity and predictive value in the diagnosis of brucellosis.对玫瑰红平板试验进行创新性改良，可提高其在布鲁氏菌病诊断中的特异性、敏感性和预测价值。
J Microbiol Methods. 2014 Feb;97:25-8. doi: 10.1016/j.mimet.2013.12.005. Epub 2013 Dec 15.
7
An overview of Brucellosis.布鲁氏菌病概述。
Mymensingh Med J. 2011 Oct;20(4):742-7.
8
Human brucellosis.人类布鲁氏菌病
Lancet Infect Dis. 2007 Dec;7(12):775-86. doi: 10.1016/S1473-3099(07)70286-4.
9
Sensitivity of bone marrow aspirates in the diagnosis of visceral leishmaniasis.骨髓穿刺液在内脏利什曼病诊断中的敏感性。
Am J Trop Med Hyg. 2005 Jun;72(6):811-4.