Briggs G G, Berman M L, Lange S, Riker J, Rettenmaier M, DiSaia P
Gynecol Oncol. 1985 Nov;22(3):288-93. doi: 10.1016/0090-8258(85)90042-3.
Postoperative pain was controlled in 42 patients with either continuous intravenous (iv) or scheduled intramuscular morphine following surgery for gynecologic cancers. In this double-blind study, no statistical differences were found in pain control or rate of complications between the two methods of administration. Both routes were effective in controlling pain without producing major toxicity. Initial doses were based on the patient's weight and then adjusted every 4 hr. We conclude that both methods are safe and effective but that continuous iv infusion is the preferred route because of the ease of administration, elimination of multiple intramuscular injections, and possibly more even pain control.
42例妇科癌症手术后的患者，通过持续静脉注射（iv）或定时肌肉注射吗啡来控制术后疼痛。在这项双盲研究中，两种给药方法在疼痛控制或并发症发生率方面未发现统计学差异。两种途径在控制疼痛方面均有效，且未产生重大毒性。初始剂量根据患者体重确定，然后每4小时调整一次。我们得出结论，两种方法都是安全有效的，但持续静脉输注是首选途径，因为其给药方便，避免了多次肌肉注射，并且可能能更均匀地控制疼痛。
