van Eijl Ruben H M, Buitenhuis Patrick J, Stegeman Inge, Klis Sjaak F L, Grolman Wilko
Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Laryngoscope. 2017 Feb;127(2):476-487. doi: 10.1002/lary.26154. Epub 2016 Nov 2.
OBJECTIVES/HYPOTHESIS: The variability in speech perception between cochlear implant users is thought to result from the degeneration of the auditory nerve. Degeneration of the auditory nerve, histologically assessed, correlates with electrophysiologically acquired measures, such as electrically evoked compound action potentials (eCAPs) in experimental animals. To predict degeneration of the auditory nerve in humans, where histology is impossible, this paper reviews the correlation between speech perception and eCAP recordings in cochlear implant patients.
PubMed and Embase.
We performed a systematic search for articles containing the following major themes: cochlear implants, evoked potentials, and speech perception. Two investigators independently conducted title-abstract screening, full-text screening, and critical appraisal. Data were extracted from the remaining articles.
Twenty-five of 1,429 identified articles described a correlation between speech perception and eCAP attributes. Due to study heterogeneity, a meta-analysis was not feasible, and studies were descriptively analyzed. Several studies investigating presence of the eCAP, recovery time constant, slope of the amplitude growth function, and spatial selectivity showed significant correlations with speech perception. In contrast, neural adaptation, eCAP threshold, and change with varying interphase gap did not significantly correlate with speech perception in any of the identified studies.
Significant correlations between speech perception and parameters obtained through eCAP recordings have been documented in literature; however, reporting was ambiguous. There is insufficient evidence for eCAPs as a predictive factor for speech perception. More research is needed to further investigate this relation. Laryngoscope, 2016 127:476-487, 2017.
目的/假设：人工耳蜗使用者之间言语感知的变异性被认为是由听神经退变所致。组织学评估的听神经退变与实验动物中通过电生理获得的指标相关，如电诱发复合动作电位（eCAPs）。为了预测无法进行组织学检查的人类听神经退变情况，本文综述了人工耳蜗植入患者言语感知与eCAP记录之间的相关性。
PubMed和Embase。
我们对包含以下主要主题的文章进行了系统检索：人工耳蜗、诱发电位和言语感知。两名研究者独立进行标题-摘要筛选、全文筛选和批判性评价。从其余文章中提取数据。
在1429篇已识别文章中，有25篇描述了言语感知与eCAP属性之间的相关性。由于研究的异质性，无法进行荟萃分析，对研究进行了描述性分析。几项研究调查了eCAP的存在、恢复时间常数、振幅增长函数的斜率和空间选择性，结果显示与言语感知有显著相关性。相比之下，在任何已识别的研究中，神经适应性、eCAP阈值以及不同相间间隙下的变化与言语感知均无显著相关性。
文献中已记录了言语感知与通过eCAP记录获得的参数之间存在显著相关性；然而，报告并不明确。没有足够的证据表明eCAP可作为言语感知的预测因素。需要更多研究来进一步探究这种关系。《喉镜》，2016年127卷：476 - 487页，2017年。
