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印度南部人群中神经发育障碍(NDD)的患病率估计

Prevalence Estimates of Neurodevelopmental Disorders (NDD) in a South Indian Population.

作者信息

Nair Krishna S, George Roana Liz, Remya V R, P A Ramitha, Saji Chinthu V, Mullasseril Rinku Raj, Shenoi Rajesh A, Nair Jayasree, Krishna Rajee, K N Krishnakumar, Thomas Amal, Varughese Deepthi, Chandra Goutam, Mohanakumar Kochupurackal P, Rajamma Usha

机构信息

Inter University Centre for Biomedical Research & Super Speciality Hospital (IUCBR & SSH), Mahatma Gandhi University Campus at Thalappady, Kottayam, Kerala, India.

District Early Intervention Centre (DEIC), National Health Mission (NHM), Kottayam, Kerala, India.

出版信息

Ann Neurosci. 2025 Jul 11:09727531251348188. doi: 10.1177/09727531251348188.

Abstract

BACKGROUND

Neurodevelopmental disorders (NDDs) represent a significant public health concern globally, yet comprehensive prevalence data in India, a nation with 1.4 billion inhabitants, remains scarce. Limited systematic investigations have hindered effective public health planning.

PURPOSE

This study aims to evaluate the prevalence of NDDs within a local Panchayath population in Kottayam, Kerala, employing a community-based methodology.

METHODS

A two-phase cross-sectional study was conducted. Phase I involved a door-to-door survey to screen for NDDs, targeting the entire Panchayath population. In Phase II, individuals screened as at-risk underwent detailed clinical assessments. The collected data were analysed to determine the overall and specific prevalence of various NDDs.

RESULTS

The overall prevalence of NDDs in the surveyed population ( = 26,465) after Phase II was 0.80% (1 in 125), with a significantly higher prevalence of 1.38% (1 in 72) in children under 12 years. The prevalence rates of specific disorders included epilepsy (0.38%, 0.50% in children), specific learning disability (0.10%, 0.29% in children), attention deficit hyperactivity disorder (0.05%, 0.32% in children), developmental language disorder (0.026%, 0.029% in children), and autism spectrum disorder (ASD) (0.02%, 0.06% in children).

CONCLUSION

A key strength of the study was its inclusion of the entire Panchayath population in Phase I, filling a significant gap in the literature on NDD prevalence at the community level in India. As one of the first community-level estimates, it underscores the need for targeted public health strategies, particularly for children. The findings offer crucial data to guide policymakers and public health officials in planning interventions to reduce the burden of NDDs in the region.

摘要

背景

神经发育障碍(NDDs)是全球重大的公共卫生问题,但在拥有14亿人口的印度,全面的患病率数据仍然匮乏。有限的系统调查阻碍了有效的公共卫生规划。

目的

本研究旨在采用基于社区的方法,评估喀拉拉邦科塔亚姆当地一个村委会人群中神经发育障碍的患病率。

方法

进行了一项两阶段横断面研究。第一阶段进行挨家挨户调查,以筛查神经发育障碍,目标人群为整个村委会人口。在第二阶段,被筛查为有风险的个体接受详细的临床评估。对收集到的数据进行分析,以确定各种神经发育障碍的总体患病率和特定患病率。

结果

第二阶段调查人群(n = 26465)中神经发育障碍的总体患病率为0.80%(1/125),12岁以下儿童的患病率显著更高,为1.38%(1/72)。特定疾病的患病率包括癫痫(0.38%;儿童为0.50%)、特定学习障碍(0.10%;儿童为0.29%)、注意力缺陷多动障碍(0.05%;儿童为0.32%)、发育性语言障碍(0.026%;儿童为0.029%)和自闭症谱系障碍(ASD)(0.02%;儿童为0.06%)。

结论

该研究的一个关键优势是在第一阶段纳入了整个村委会人口,填补了印度社区层面神经发育障碍患病率文献中的一个重大空白。作为首批社区层面的估计之一,它强调了针对性公共卫生策略的必要性,尤其是针对儿童。这些发现为指导政策制定者和公共卫生官员规划干预措施以减轻该地区神经发育障碍负担提供了关键数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c998/12254137/5b1d47062df3/10.1177_09727531251348188-fig1.jpg

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