This study presents a multiscale modeling framework for simulating and predicting the behavior and biodistribution of nanoparticles (), focusing on applications such as targeted drug delivery. The framework encompasses two coupled models: (1) a DeepONet-enabled Fokker-Planck equation to model the NP drift-diffusion in the red-blood cell-free layer () that predicts NP margination and concentration profiles taking hematocrit and vessel radius as inputs, built on top of a hemorheological model of shear-induced blood flow and (2) a physiologically based pharmacokinetic (PBPK) model that uses the predicted concentration profiles in microvasculature to inform the biodistribution of NPs across different organ in the body.