Berger R, Bernheim A, Gluckman E, Gisselbrecht C
Br J Haematol. 1980 Aug;45(4):565-8. doi: 10.1111/j.1365-2141.1980.tb07179.x.
The effect of cyclophosphamide metabolites was studied on chromosomes of FAnconi anaemia patients, parents and controls. A high susceptibility of Fa patients chromosomes was observed when low concentrations of sera of a cyclophosphamide-treated patient was added to PHA-stimulated lymphocyte cultures. No effect was observed with comparable concentrations on cells from FA parents or controls. The high susceptibility of FA cells is discussed in relation to the high sensitivity of FA patients to cyclophosphamide when used as a conditioning drug for bone marrow graft.
研究了环磷酰胺代谢产物对范可尼贫血患者、其父母及对照者染色体的影响。当将一名经环磷酰胺治疗患者的低浓度血清添加到PHA刺激的淋巴细胞培养物中时，观察到范可尼贫血患者的染色体具有高度易感性。对范可尼贫血患者父母及对照者的细胞使用相当浓度的血清时未观察到影响。结合范可尼贫血患者在用作骨髓移植预处理药物时对环磷酰胺的高敏感性，讨论了范可尼贫血细胞的高度易感性。
