Antonio Jose, Antonio Brandi, Aragon Alan, Bustillo Erik, Candow Darren, Collins Rick, Davila Edwin, Durkin Bob, Kalman Douglas, Lockwood Chris, Mills Scotty, Stout Jeffrey R
NSU Florida, Department of Health and Human Performance, College of Health Care Sciences, Davie, FL, USA.
University of Central Florida, School of Kinesiology and Rehabilitation Sciences, Orlando, Florida, USA.
J Int Soc Sports Nutr. 2025 Dec;22(1):2534128. doi: 10.1080/15502783.2025.2534128. Epub 2025 Jul 15.
Dietary supplement use is popular among fitness enthusiasts as well as competitive athletes. There is, however, confusion regarding the regulatory framework as well as the basic science regarding the use of supplements. Although there is an extensive body of scientific and legal writings on dietary supplements, several misconceptions persist vis-à-vis this category. Thus, the following questions will be addressed in this review. 1) Are dietary supplements regulated by the Food and Drug Administration? 2) Are foods and supplements regulated similarly? 3) What is the role of the Federal Trade Commission? 4) Besides federal regulations for dietary supplements, do state laws also regulate the category? 5) If a supplement company funds a study, does that automatically call into question the results? 6) Can diet alone provide everything you need without using supplements? 7) Is it necessary to conduct randomized controlled trials (RCTs) on dietary supplements? 8) How safe are supplements compared to OTC drugs? 9) Where can consumers find accurate information about supplements? 10) Why does the NIH fund dietary supplement research related to disease, yet findings cannot be marketed by supplement companies? 11) What is the size of the dietary supplement industry compared to the pharmaceutical industry? 12) How can I know if a dietary supplement is safe and free of banned substances? Similar to our prior papers, a team of legal and science scholars evaluated the evidence on these salient questions.
膳食补充剂的使用在健身爱好者以及竞技运动员中都很普遍。然而,对于膳食补充剂的监管框架以及其使用的基础科学存在困惑。尽管有大量关于膳食补充剂的科学和法律著作,但关于这一类别仍存在一些误解。因此,本综述将探讨以下问题。1)膳食补充剂是否受美国食品药品监督管理局监管?2)食品和补充剂的监管方式是否类似?3)联邦贸易委员会的作用是什么?4)除了联邦对膳食补充剂的规定外,州法律是否也对这一类别进行监管?5)如果一家补充剂公司资助一项研究,这是否会自动使研究结果受到质疑?6)仅靠饮食能否提供无需使用补充剂时所需的一切?7)是否有必要对膳食补充剂进行随机对照试验(RCT)?8)与非处方药相比,补充剂有多安全?9)消费者在哪里可以找到关于补充剂的准确信息?10)为什么美国国立卫生研究院资助与疾病相关的膳食补充剂研究,但研究结果却不能由补充剂公司进行营销?11)与制药行业相比,膳食补充剂行业的规模有多大?12)我如何知道一种膳食补充剂是否安全且不含违禁物质?与我们之前的论文类似,一组法律和科学学者评估了这些关键问题的证据。