Petersen R C
Psychopharmacology (Berl). 1977 May 9;52(3):283-9. doi: 10.1007/BF00426713.
Two experiments were performed to determine the locus of the amnestic effects of scopolamine in man. The first experiment involved 24 volunteers receiving one of three doses of scopolamine (5, 8 or 10 microng/kg) or a placebo, intravenously. The subjects were tested for retention of material learned prior to administration of the drug, acquisition of new information, and retention of material learned while under the influence of the drug. Results indicated that scopolamine has its primary effect on the acquisition of new material and less of an effect on the retrieval of information already learned. The second experiment was designed to refine and expand upon the results of the first and involved 18 volunteers receiving eith 5 or 10 microng/kg of scopolamine or a placebo, intravenously. The subjects were given four trials to learn a list of verbal materials, and their recall for that material was measured at various intervals up to 24 h. These results confirmed those of the first experiment in that the predominant influence of the drug was to impair the acquisition of new information. Implications of these results for memory mechanisms are discussed.
进行了两项实验以确定东莨菪碱对人类记忆缺失作用的位点。第一项实验有24名志愿者，他们静脉注射三种剂量（5、8或10微克/千克）的东莨菪碱之一或安慰剂。对受试者进行测试，以了解给药前所学材料的记忆保持情况、新信息的获取情况以及在药物影响下所学材料的记忆保持情况。结果表明，东莨菪碱主要影响新材料的获取，而对已学信息的检索影响较小。第二项实验旨在完善和扩展第一项实验的结果，有18名志愿者静脉注射5或10微克/千克的东莨菪碱或安慰剂。让受试者进行四次试验来学习一系列文字材料，并在长达24小时的不同间隔时间测量他们对该材料的回忆。这些结果证实了第一项实验的结果，即药物的主要影响是损害新信息的获取。讨论了这些结果对记忆机制的意义。
