Wang Kai, Lu Dufu
Department of Anesthesiology, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Front Oncol. 2025 Jul 1;15:1568365. doi: 10.3389/fonc.2025.1568365. eCollection 2025.
This study aims to explore the cooperative networks among authors, nations, organizations, and publications specializing in extracellular vesicle-angiogenesis, to evaluate the foundational knowledge, and to pinpoint future research directions and new topics.
We extracted all relevant articles from the Web of Science Core Collection (WoSCC) and reviews related to extracellular vesicle-angiogenesis published between January 1999 and December 2023, which met our inclusion criteria. We conducted author and keyword composition analyses using VOSviewer 1.6.18. Furthermore, we utilized Citespace 5.8 to analyze journals, institutions, countries, and keyword timezone maps to elucidate the knowledge network within this field.
The number of academic papers on extracellular vesicle-angiogenesis has steadily increased over the past 25 years. Researchers have closely collaborated globally, with 6,741 papers published in 4,393 academic journals across 111 countries or regions. Shanghai Jiao Tong University has the highest publication volume. Immunology and cancer are the primary focus areas, with and being significant journals in this field. Cluster analysis results indicate that the relationship between extracellular vesicle-angiogenesis and tumors, inflammation, and regenerative medicine are the three main subfields in this domain. Current research hotspots include mesenchymal stem cells, exosomes, angiogenesis, circulating microRNAs, angiogenesis, and tumor microenvironment.
This bibliometric study utilized visualization techniques to develop a knowledge map of extracellular vesicle-angiogenesis, revealing the significance of extracellular vesicles in tumor evasion by regulating intercellular communication between tumor cells and immune cells, and discussed the potential of exosomal biomarkers in precision medicine.
本研究旨在探索专注于细胞外囊泡-血管生成的作者、国家、组织和出版物之间的合作网络，评估基础知识，并确定未来的研究方向和新主题。
我们从科学网核心合集（WoSCC）中提取了所有符合我们纳入标准的、与1999年1月至2023年12月期间发表的细胞外囊泡-血管生成相关的文章和综述。我们使用VOSviewer 1.6.18进行作者和关键词组成分析。此外，我们利用Citespace 5.8分析期刊、机构、国家和关键词时区图，以阐明该领域内的知识网络。
在过去25年中，关于细胞外囊泡-血管生成的学术论文数量稳步增加。研究人员在全球范围内密切合作，111个国家或地区的4393种学术期刊发表了6741篇论文。上海交通大学的发表量最高。免疫学和癌症是主要关注领域，[具体期刊名称未给出]和[具体期刊名称未给出]是该领域的重要期刊。聚类分析结果表明，细胞外囊泡-血管生成与肿瘤、炎症和再生医学之间的关系是该领域的三个主要子领域。当前的研究热点包括间充质干细胞、外泌体、血管生成、循环微小RNA、血管生成和肿瘤微环境。
这项文献计量学研究利用可视化技术绘制了细胞外囊泡-血管生成的知识图谱，揭示了细胞外囊泡通过调节肿瘤细胞与免疫细胞之间的细胞间通讯在肿瘤逃逸中的重要性，并讨论了外泌体生物标志物在精准医学中的潜力。
