Miyamae Nao, Ogai Kazuhiro, Kunimitsu Mao, Okamoto Shigefumi, Fujiwara Masayuki, Nagai Makoto, Okuwa Mayumi, Oe Makoto
Department of Fundamental Nursing, School of Nursing, Hyogo Medical University, Kobe, Japan.
Department of Bio-Engineering Nursing, Graduate School of Nursing, Ishikawa Prefectural Nursing University, Kahoku, Japan.
Case Rep Oncol. 2025 Jun 24;18(1):958-964. doi: 10.1159/000546634. eCollection 2025 Jan-Dec.
Identifying the skin microbiome associated with severe radiodermatitis could lead to the development of preventive care strategies and early healing interventions, which are currently lacking. In this study, we investigated changes in the skin microbiome of a patient with head and neck cancer who developed severe radiodermatitis from the initiation of radiation therapy to the resolution of dermatitis.
An 82-year-old male underwent chemoradiotherapy with cisplatin (69.96 Gy/33 fractions) for recurrent laryngeal cancer after a total laryngectomy. At baseline, accounted for 64.3% of the skin microbiome and for 23.2%. During the occurrence of moist desquamation associated with severe radiodermatitis, decreased sharply to 0.2%, whereas increased to 91.0%. Species-level analysis revealed that was dominant at 50.6%, whereas and were identified at 0.4% and 1.7%, respectively.
These findings demonstrated that changes in the skin microbiome occur during the progression of severe radiodermatitis. The reduction in and overgrowth of , particularly , suggest their involvement in the development of severe radiodermatitis in patients with head and neck cancer.
确定与严重放射性皮炎相关的皮肤微生物群可能会促成预防性护理策略和早期愈合干预措施的发展，而目前这些措施尚不存在。在本研究中，我们调查了一名头颈癌患者从放疗开始到皮炎消退期间皮肤微生物群的变化，该患者发生了严重放射性皮炎。
一名82岁男性在全喉切除术后接受了顺铂同步放化疗（69.96 Gy/33次分割）治疗复发性喉癌。基线时，[具体菌种1]占皮肤微生物群的64.3%，[具体菌种2]占23.2%。在与严重放射性皮炎相关的湿性脱皮发生期间，[具体菌种1]急剧下降至0.2%，而[具体菌种2]增加至91.0%。种水平分析显示，[具体菌种3]占主导地位，为50.6%，而[具体菌种4]和[具体菌种5]分别占0.4%和1.7%。
这些发现表明，在严重放射性皮炎的进展过程中会发生皮肤微生物群的变化。[具体菌种1]的减少和[具体菌种2]的过度生长，尤其是[具体菌种3]，表明它们参与了头颈癌患者严重放射性皮炎的发生发展。
