School of Public Health, Peking University Health Science Center, Beijing 100191, China.
Nutrients. 2024 Sep 28;16(19):3284. doi: 10.3390/nu16193284.
The global obesity issue is growing increasingly serious, impacting personal health, economic development, and the sustainability of medical systems. There is an urgent need for effective weight loss strategies that can be widely implemented. This study conducted a 90-day randomized controlled trial to assess the impact of meal replacement products on weight management and glycolipid metabolism in adults with obesity. Adults with obesity meeting the inclusion and exclusion criteria were divided into three groups: the meal replacement group ( = 19), the diet control group ( = 19), and the normal diet group ( = 22). The meal replacement group used specially formulated meal replacement products for dinner, and the diet control group reduced the intake of staple food at lunch, both controlling daily energy intake between 1200 kcal and 1300 kcal, while the normal diet group maintained their regular dietary habits. Relevant indicators were measured at baseline and after 45 and 90 days of intervention. The results showed that both the meal replacement group and the diet control group experienced significant decreases in weight, BMI, and body fat percentage, with the meal replacement group showing a more pronounced weight loss effect. The weight loss of the meal replacement group at 45 and 90 days was 4.44 ± 1.84 kg and 7.38 ± 3.24 kg, the diet control group was 2.62 ± 2.28 kg and 4.08 ± 2.94 kg, and the normal diet group was 0.66 ± 1.73 kg and 0.97 ± 2.02 kg. The decrease in BMI at 45 and 90 days for the meal replacement group was 1.08 ± 0.78 kg/m and 2.17 ± 1.57 kg/m, for the diet control group was 0.82 ± 0.80 kg/m and 1.39 ± 1.16 kg/m, and for the normal diet group was 0.19 ± 0.71 kg/m and 0.21 ± 0.96 kg/m. The decrease in body fat percentage at 45 and 90 days for the meal replacement group was 1.76 ± 0.68% and 3.67 ± 2.62%, for the diet control group was 1.02 ± 1.11% and 1.52 ± 1.79%, and for the normal diet group was 0.81 ± 1.09% and 0.53 ± 0.93%. In addition, the decrease in BMI and body fat percentage in the meal replacement group was also significantly higher than in the other two groups. In terms of metabolic indicators, there were no significant differences in the changes of blood pressure, blood lipids, blood sugar, and ALT levels among the three groups during the intervention period. In summary, the results indicate that meal replacement products can significantly reduce weight and body fat percentage without affecting metabolic health.
全球肥胖问题日益严重，影响个人健康、经济发展和医疗系统的可持续性。因此，迫切需要能够广泛实施的有效减肥策略。本研究进行了为期 90 天的随机对照试验，以评估代餐产品对肥胖成年人体重管理和糖脂代谢的影响。
代餐组（n=19）、饮食控制组（n=19）和正常饮食组（n=22）。代餐组晚餐使用特制的代餐产品，饮食控制组午餐减少主食摄入量，两组均控制每日能量摄入在 1200-1300 千卡之间，而正常饮食组保持其常规饮食习惯。在基线和干预 45 天和 90 天后测量相关指标。
结果表明，代餐组和饮食控制组的体重、BMI 和体脂百分比均显著下降，其中代餐组的减肥效果更为明显。代餐组在 45 天和 90 天的减重分别为 4.44±1.84 千克和 7.38±3.24 千克，饮食控制组分别为 2.62±2.28 千克和 4.08±2.94 千克，正常饮食组分别为 0.66±1.73 千克和 0.97±2.02 千克。代餐组 BMI 在 45 天和 90 天的下降分别为 1.08±0.78 千克/平方米和 2.17±1.57 千克/平方米，饮食控制组分别为 0.82±0.80 千克/平方米和 1.39±1.16 千克/平方米，正常饮食组分别为 0.19±0.71 千克/平方米和 0.21±0.96 千克/平方米。代餐组体脂百分比在 45 天和 90 天的下降分别为 1.76±0.68%和 3.67±2.62%，饮食控制组分别为 1.02±1.11%和 1.52±1.79%，正常饮食组分别为 0.81±1.09%和 0.53±0.93%。此外，代餐组 BMI 和体脂百分比的下降也明显高于其他两组。在代谢指标方面，三组在干预期间血压、血脂、血糖和 ALT 水平的变化均无显著差异。
综上所述，研究结果表明，代餐产品可显著减轻体重和体脂百分比，且不会影响代谢健康。
