Foresta C, Zanatta G P, Busnardo B, Scanelli G, Scandellari C
J Endocrinol Invest. 1985 Aug;8(4):377-9. doi: 10.1007/BF03348518.
The aim of this study was to ascertain whether there was an interrelationship between male osteoporosis, calcitonin and androgens. Ten young hypogonadal osteoporotic men were studied: testosterone and calcitonin plasma levels were measured before and after therapy with testosterone enanthate (200 mg im every three weeks for four months). In these patients testosterone and calcitonin plasma levels were significantly lower than controls, before therapy (p less than 0.001 and p less than 0.01 respectively). Testosterone treatment significantly increased (p less than 0.05) serum calcitonin. The conclusion was that androgen deficiency may cause osteoporosis also by decreasing calcitonin secretion.
本研究的目的是确定男性骨质疏松症、降钙素和雄激素之间是否存在相互关系。对10名患有性腺功能减退的骨质疏松症青年男性进行了研究：在使用庚酸睾酮治疗前和治疗后（每三周肌肉注射200毫克，共四个月）测量血浆睾酮和降钙素水平。在这些患者中，治疗前血浆睾酮和降钙素水平显著低于对照组（分别为p<0.001和p<0.01）。睾酮治疗使血清降钙素显著升高（p<0.05）。结论是雄激素缺乏也可能通过减少降钙素分泌而导致骨质疏松症。
