Roy Sayan, Garg Divya, Uyeda Christopher
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Tetrahedron Lett. 2025 Sep 15;168. doi: 10.1016/j.tetlet.2025.155705. Epub 2025 Jun 16.
A nickel catalyst promotes the reductive annulation of alkenes using 1,3-dihalopropanes to provide substituted cyclopentanes. Mechanistic studies indicate that activation of the dihaloalkane occurs by a halogen-atom abstraction mechanism to generate a carbon-centered radical. Overall, the method provides direct access to saturated ring-systems from simple acyclic reaction partners.
镍催化剂利用1,3 - 二卤丙烷促进烯烃的还原环化反应，以提供取代的环戊烷。机理研究表明，二卤代烷的活化是通过卤原子夺取机理发生的，从而生成以碳为中心的自由基。总体而言，该方法能从简单的无环反应底物直接得到饱和环系。
