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配方奶蛋白质含量与婴儿早期生长的关联：系统评价和荟萃分析。

The Association of Formula Protein Content and Growth in Early Infancy: A Systematic Review and Meta-Analysis.

机构信息

Innovation Center, Nutrition and Metabolism Research Division, Heilongjiang Feihe Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.

PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Xueyuan Road 38, Haidian, Beijing 100083, China.

出版信息

Nutrients. 2022 May 28;14(11):2255. doi: 10.3390/nu14112255.

DOI:10.3390/nu14112255
PMID:35684055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9183142/
Abstract

This systematic review aimed to examine differences in growth outcomes between breastfed infants and infants fed with formula with different protein/energy ratios during the first six months of life. We conducted a systematic review in the PubMed, Web of Science, and Springer databases. Twenty clinical trials qualified for inclusion. We extracted data about the growth outcomes of infants who were exclusive breastfed or exclusively infant formula fed in the first six months and used a meta-analysis to pool the finding data. We categorized study formulas into four groups according to their protein content: <1.8, 1.8−2.0, 2.1−2.2, and >2.2 g/100 kcal. In the first month of life, growth was not different between formula- and breastfed infants. During 2−3 months of life, growth was faster in infants who consumed formulas with protein contents higher than 2.0 g/100 kcal. After 3 months, formula-fed infants grew faster than breastfed infants. Our meta-analysis indicated that the growth outcomes of infants fed with infant formula with a relatively low protein/energy ratios, compared with that a relatively high protein/energy ratio, were close to those of breastfed infants.

摘要

本系统评价旨在研究在生命的头六个月中，母乳喂养婴儿和不同蛋白质/能量比配方奶喂养婴儿的生长结果差异。我们在 PubMed、Web of Science 和 Springer 数据库中进行了系统评价。20 项临床试验符合纳入标准。我们提取了前六个月中纯母乳喂养或纯配方奶喂养婴儿的生长结果数据，并使用荟萃分析来汇总发现数据。我们根据蛋白质含量将研究配方分为四组：<1.8、1.8-2.0、2.1-2.2 和>2.2 g/100 kcal。在生命的第一个月，配方奶喂养和母乳喂养婴儿的生长没有差异。在 2-3 个月时，摄入蛋白质含量高于 2.0 g/100 kcal 的配方奶的婴儿生长更快。3 个月后，配方奶喂养的婴儿比母乳喂养的婴儿生长更快。我们的荟萃分析表明，与高蛋白质/能量比相比，低蛋白质/能量比配方奶喂养婴儿的生长结果与母乳喂养婴儿接近。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/669c814c7688/nutrients-14-02255-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/f5886b5fc8ee/nutrients-14-02255-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/89f0368cde9a/nutrients-14-02255-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/c44c8df40712/nutrients-14-02255-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/7b9f87a75052/nutrients-14-02255-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/5070d0a30ca5/nutrients-14-02255-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/669c814c7688/nutrients-14-02255-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/f5886b5fc8ee/nutrients-14-02255-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/796060a5e4f4/nutrients-14-02255-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/89f0368cde9a/nutrients-14-02255-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/c44c8df40712/nutrients-14-02255-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/7b9f87a75052/nutrients-14-02255-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/5070d0a30ca5/nutrients-14-02255-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c38/9183142/669c814c7688/nutrients-14-02255-g007.jpg

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Breast Milk: A Meal Worth Having.母乳：一顿值得享用的膳食。
Front Nutr. 2022 Jan 26;8:800927. doi: 10.3389/fnut.2021.800927. eCollection 2021.
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Breastfeeding in a Global Context: Epidemiology, Impact, and Future Directions.全球背景下的母乳喂养：流行病学、影响及未来方向
不含A1型β-酪蛋白的牛奶制成的婴儿配方奶粉对生长和舒适度的影响：一项随机对照试验。
Food Sci Nutr. 2025 Jul 15;13(7):e70606. doi: 10.1002/fsn3.70606. eCollection 2025 Jul.
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Anthropometry and Body Composition in Childhood: Follow-Up of a Randomised, Double-Blinded Controlled Trial With a Modified, Low-Protein Infant Formula During Infancy.儿童期人体测量学与身体成分：一项关于婴儿期使用改良低蛋白婴儿配方奶粉的随机双盲对照试验的随访研究
Pediatr Obes. 2025 Oct;20(10):e70038. doi: 10.1111/ijpo.70038. Epub 2025 Jul 4.
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