Golubev D B, Karpukhin G I, Galitarov S S, Denisov G M
J Hyg (Lond). 1985 Oct;95(2):493-504. doi: 10.1017/s0022172400062914.
In April-May 1980, two independent outbreaks of influenza-like illness occurred in Leningrad among children's-home children aged from 3 months to 2 years (of 68 children under observation, 50 became ill) and among boarding-school pupils aged 15-17 years (of 50 pupils under observation, 13 became ill). A total of five influenza A virus strains were derived from one clinically healthy and three affected children of the children's home. Similar viruses were obtained from one affected boarding-school pupil and from an infected woman aged 24 years (a sporadic case within a household). On the basis of laboratory findings, all these seven strains were identified as influenza A H2N2 subtype strains. Six of the affected children showed significant seroconversion only to H2 haemagglutinin from February to May 1980. Type A influenza H2N2 virus was isolated from three persons, including the sporadic case, who also showed significant seroconversion to H2 haemagglutinin. H2N2 influenza A virus was isolated on two occasions, at a 7-day interval, from the girl N. Ju. Laboratory findings obtained from the study of the viruses isolated using up-to-date immunological and molecular-biochemical techniques enable us to conclude the following. The A/Leningrad/80 isolates belong to H2N2 sero-subtype. The viruses isolated are similar but not identical to the A/Singapore/I/57 reference strain in details of polypeptide and gene composition.
1980年4月至5月期间，列宁格勒发生了两起独立的流感样疾病疫情。一起发生在3个月至2岁的儿童福利院儿童中（在68名接受观察的儿童中，50名患病），另一起发生在15至17岁的寄宿学校学生中（在50名接受观察的学生中，13名患病）。从儿童福利院一名临床健康儿童和三名患病儿童中总共分离出五株甲型流感病毒毒株。从一名患病的寄宿学校学生和一名24岁受感染女性（一户家庭中的散发病例）身上也获得了类似病毒。根据实验室检测结果，所有这七株毒株均被鉴定为甲型H2N2亚型流感毒株。6名患病儿童在1980年2月至5月期间仅对H2血凝素出现显著的血清转化。甲型H2N2流感病毒从包括散发病例在内的三人身上分离得到，这三人对H2血凝素也出现了显著的血清转化。从女孩N. Ju身上间隔7天两次分离出H2N2甲型流感病毒。运用最新的免疫学和分子生化技术对分离出的病毒进行研究所得的实验室检测结果使我们能够得出以下结论。A/列宁格勒/80分离株属于H2N2血清亚型。分离出的病毒在多肽和基因组成细节上与A/新加坡/I/57参考毒株相似但并不相同。
