Hay A J, Skehel J J, Webster R G
J Gen Virol. 1979 Oct;45(1):245-8. doi: 10.1099/0022-1317-45-1-245.
The genetic compositions of four antigenic variants of A/Memphis/1/71 (H3N2) influenza virus, which were selected by growth in the presence of monoclonal antibodies against the haemagglutinin, were compared. The results indicate that the mutant haemagglutinin genes can be differentiated by polyacrylamide gel electrophoresis of the double stranded RNA hybrids formed between virion RNA and transcripts isolated from infected cells.
对通过在抗血凝素单克隆抗体存在下培养而筛选出的A/孟菲斯/1/71（H3N2）流感病毒的四种抗原变体的基因组成进行了比较。结果表明，通过对病毒粒子RNA与从感染细胞中分离的转录本形成的双链RNA杂交体进行聚丙烯酰胺凝胶电泳，可以区分突变的血凝素基因。
