Fang Liang, Wang Peng, Xie Tianqin, Ding Shuai, Wang Ting, Zhang Jiajia, Zhang Aiguo, Zhu Peng, Zhu Daomin
Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Department of Sleep Disorders, Anhui Mental Health Center, Hefei Anhui, China.
Front Psychiatry. 2025 Jul 2;16:1574864. doi: 10.3389/fpsyt.2025.1574864. eCollection 2025.
Patients with major depressive disorder (MDD) may experience cognitive dysfunction and sleep disorders. Limited research exists on the neurophysiological mechanisms that connect sleep efficiency and cognitive function in individuals with MDD. The study aims to investigate the link between sleep efficiency, mental abilities, and levels of serum C-reactive protein (CRP) in individuals diagnosed with MDD.
A total of 101 individuals diagnosed with MDD were selected and categorized into two groups: the normal sleep efficiency group (NSE) with SE ≥90% and the group with lower sleep efficiency (LSE) with SE <Eth) All patients underwent polysomnography (PSG), event-related potentials (ERPs) tests, and CRP detection. The study used multiple linear regression and bootstrapped mediation analysis to explore the correlation between SE, ERPs latency, and CRP.
The N2, P3a, and P3b latencies were longer in the LSE group compared to the NSE group ( = 0.036, = 0.013, < 0.001). N2 (Pr = -122.182), P3a (Pr = -109.597), P3b (Pr = -151.960), and CRP (Pr = -3.768) are significantly associated with SE. A strong correlation was found between CRP (Pr = 9.414) and P3b latency. After controlling for gender and other pertinent variables, the subsequent investigation revealed a direct correlation between CRP and P3b latency, specifically within the cohort of depression patients exhibiting low SE. CRP mediated the association between SE and P3b latency.
Low SE with MDD was associated with chronic inflammation and impaired cognitive function, suggesting that inflammation may act as a potential mediating factor in the relationship between SE and impaired cognitive function.
重度抑郁症（MDD）患者可能会出现认知功能障碍和睡眠障碍。关于MDD患者睡眠效率与认知功能之间联系的神经生理机制的研究有限。本研究旨在调查被诊断为MDD的个体的睡眠效率、心理能力和血清C反应蛋白（CRP）水平之间的联系。
共选取101名被诊断为MDD的个体，并将其分为两组：睡眠效率正常组（NSE），睡眠效率（SE）≥90%；睡眠效率较低组（LSE），SE<90%。所有患者均接受多导睡眠图（PSG）、事件相关电位（ERP）测试和CRP检测。本研究采用多元线性回归和自抽样中介分析来探讨SE、ERP潜伏期和CRP之间的相关性。
与NSE组相比，LSE组的N2、P3a和P3b潜伏期更长（P = 0.036，P = 0.013，P<0.001）。N2（β = -122.182）、P3a（β = -109.597）、P3b（β = -151.960）和CRP（β = -3.768）与SE显著相关。发现CRP（β = 9.414）与P3b潜伏期之间存在强相关性。在控制性别和其他相关变量后，后续调查显示CRP与P3b潜伏期之间存在直接相关性，特别是在SE较低的抑郁症患者队列中。CRP介导了SE与P3b潜伏期之间的关联。
MDD患者的低SE与慢性炎症和认知功能受损有关，表明炎症可能是SE与认知功能受损之间关系的潜在中介因素。
