Xu Shi Qi, Dang De Xin
Institute of Physical Education, Hubei University of Arts and Science, Xiangyang, China.
Department of Endocrinology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei University of Arts and Science, Xiangyang, China.
Rev Environ Health. 2025 Jul 21. doi: 10.1515/reveh-2025-0055.
Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is an alternative to perfluoroalkyl substance (PFAS), primarily used as surfactant in various industrial and commercial applications. Due to the presence of both perfluorinated carbon tail and sulfonate functional group in its molecular structure, OBS exhibits exceptional chemical stability and resistance to environmental degradation. Recent environmental monitoring studies have detected OBS in soil, surface and groundwater, across diverse geographic regions, indicating that human populations are inevitably exposed to this pollutant through multiple environmental pathways. As with other PFAS, the widespread distribution and environmental persistence of OBS have raised serious concerns about its potential adverse effects on human health. This review aims to summarize the current understanding of the health risks associated with OBS exposure. Moreover, we employed network toxicology analysis to identify potential molecular targets and disease associations related to OBS exposure by integrating computational target prediction algorithms with disease-related databases. Data from existing and studies suggest that OBS can bioaccumulate in multiple organs with dose-dependent manner and further induce hepatotoxicity, cardiotoxicity, immunotoxicity, as well as neurovascular, thyroid, intestinal, developmental, and pancreatic toxicity. Additionally, network toxicology analysis revealed 90 targets associated with OBS exposure, which are implicated in 417 diseases, with cancer, diabetes, and metabolic disorders emerging as key concerns. While much of the current evidence is based on animal and cellular models, this review highlights the need for further research, particularly in human clinical settings, to validate these findings and fully understand the health risks posed by OBS.
对全氟壬烯氧基苯磺酸钠（OBS）是全氟烷基物质（PFAS）的一种替代品，主要用作各种工业和商业应用中的表面活性剂。由于其分子结构中同时存在全氟化碳链和磺酸酯官能团，OBS具有出色的化学稳定性和抗环境降解能力。最近的环境监测研究在不同地理区域的土壤、地表水和地下水中检测到了OBS，这表明人类不可避免地会通过多种环境途径接触到这种污染物。与其他PFAS一样，OBS的广泛分布和环境持久性引发了人们对其对人类健康潜在不利影响的严重担忧。本综述旨在总结目前对与OBS暴露相关的健康风险的认识。此外，我们通过将计算靶点预测算法与疾病相关数据库相结合，采用网络毒理学分析来确定与OBS暴露相关的潜在分子靶点和疾病关联。现有研究数据表明，OBS可以以剂量依赖的方式在多个器官中生物蓄积，并进一步诱发肝毒性、心脏毒性、免疫毒性以及神经血管、甲状腺、肠道、发育和胰腺毒性。此外，网络毒理学分析揭示了90个与OBS暴露相关的靶点，这些靶点涉及417种疾病，癌症、糖尿病和代谢紊乱成为主要关注点。虽然目前的大部分证据基于动物和细胞模型，但本综述强调需要进一步研究，特别是在人类临床环境中，以验证这些发现并充分了解OBS带来的健康风险。
