Kaplan W D, Piez C W, Gelman R S, Laffin S M, Rosenbaum E M, Jennings C A, McCormick C A, Harris J R, Henderson I C, Atkins H L
J Nucl Med. 1985 Dec;26(12):1382-5.
Recent studies suggest that 99mTc-labeled radiocolloid (SC) compounded with hydrogen sulfide can be used to visualize lymph channels and nodes. Our study prospectively compared SC with 99mTc antimony sulfide (SbS) colloid, in 28 patients undergoing internal mammary lymphoscintigraphy. Images were recorded on a scintillation camera and computer at 0.5, 1.0, and 3.0 hr. Quantitative analysis included assessment of percent (%) injected dose in nodes, the percent remaining at the injection site, and the relative intensity of the most cephalad node compared to a 57Co standard. The mean (means) % injected dose of both radiocolloids within visualized nodes was less than 1% at each time interval, with no significant differences between means's. The means % injected dose remaining at the injection site at 3.0 hr was 83 for SbS and 76 for SC not statistically significant (N.S.). The means of the ratio of counts within the most cephalad node at 3.0 hr to counts within a 57Co standard was 0.98 for SbS and 1.03 for SC (N.S.). Clinical assessment of number of nodes visualized and extent of radiocolloid migration showed no difference between the two agents. The biological and clinical parameters for the two colloids appear similar when used for internal mammary lymphoscintigraphy.
近期研究表明，与硫化氢复合的99mTc标记放射性胶体（SC）可用于淋巴管和淋巴结显影。我们的研究前瞻性地比较了SC与99mTc硫化锑（SbS）胶体在28例接受内乳淋巴闪烁显像的患者中的应用情况。在0.5、1.0和3.0小时用闪烁相机和计算机记录图像。定量分析包括评估淋巴结中注入剂量的百分比（%）、注射部位剩余的百分比以及最头侧淋巴结与57Co标准相比的相对强度。在每个时间间隔，两种放射性胶体在显影淋巴结内的平均（均值）注入剂量百分比均小于1%，均值之间无显著差异。3.0小时时，SbS在注射部位剩余的注入剂量均值百分比为83，SC为76，无统计学意义（N.S.）。3.0小时时，最头侧淋巴结内计数与57Co标准内计数之比的均值，SbS为0.98，SC为1.03（N.S.）。对显影淋巴结数量和放射性胶体迁移范围的临床评估显示，两种制剂之间无差异。用于内乳淋巴闪烁显像时这两种胶体的生物学和临床参数似乎相似。
