Bergqvist L, Strand S E, Persson B, Hafström L, Jönsson P E
J Nucl Med. 1982 Aug;23(8):698-705.
A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of 99mTcSb2S3 colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in individual nodes can be expressed by a simple two-compartment model. The outflow of colloid from the injection site was found to be monoexponential, and the tissue volume containing the injected colloid at the injection site increased asymptotically with time. A model has been developed for calculating absorbed doses at the injection site and in organs with colloid uptake. The following absorbed doses were estimated (muGy/MBq): whole body 0.7-4.5, gonads 0-22, liver 1.0-3.9, lymph nodes up to 1000 and injection site about 10,000. Possible biological effects in the skin and effective dose equivalents have been estimated when using other lymphoscintigraphic agents.
已开发出一种使用闪烁相机的定量动力学技术，用于研究皮下注射99mTcSb2S3胶体后的淋巴引流及淋巴结摄取情况。对22例原发性恶性黑色素瘤患者进行了检查。进行了淋巴结清扫，并对185个淋巴结分别测量了放射性。单个淋巴结中胶体摄取的动力学可用一个简单的双室模型表示。发现胶体从注射部位流出呈单指数形式，注射部位含注射胶体的组织体积随时间渐近增加。已开发出一个模型，用于计算注射部位和有胶体摄取的器官的吸收剂量。估计的吸收剂量如下（微戈瑞/兆贝可）：全身0.7 - 4.5，性腺0 - 22，肝脏1.0 - 3.9，淋巴结高达1000，注射部位约10000。使用其他淋巴闪烁造影剂时，已估计了皮肤可能的生物学效应和有效剂量当量。
