Sumiyoshi Tomiki, Ikezawa Satoru, Inaba Kaori, Marumoto Tatsuro, Kusumi Ichiro, Nakagome Kazuyuki
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan.
Nippon Boehringer Ingelheim Co., Ltd, ThinkPark Tower 2-1-1 Osaki, Shinagawa, Tokyo 141-6017, Japan.
Schizophr Res Cogn. 2025 Jun 27;42:100375. doi: 10.1016/j.scog.2025.100375. eCollection 2025 Dec.
This study evaluated awareness, management, and the burden of cognitive impairment associated with schizophrenia (CIAS) in Japan. A non-interventional, cross-sectional study was conducted online between April and December 2023, involving 149 psychiatrists and 852 patients. Psychiatrists prioritized controlling positive symptoms in the acute phase of the illness, while improving social functioning was the top priority for the maintenance/stable phase. Management of CIAS was regarded as most important for the reintegration of patients into society. Psychiatrists reported higher occurrence of CIAS among inpatients than outpatients. While 72 % of psychiatrists assessed CIAS, only 15 % used the Brief Assessment of Cognition in Schizophrenia. Further, 58 % of them reported that ≤40 % of their patients received interventions for CIAS. Sixty-eight percent of patients reported current or previous experiences of CIAS. The most common CIAS-related burdens were "unable to perform tasks I could do before or they take longer" (65 %) and "unable to maintain concentration" (64 %). In patients not currently experiencing CIAS ( = 496), these burdens were reported by 52 % and 50 %, respectively. Although CIAS was generally recognized by psychiatrists, the use of appropriate assessment tools and interventions was not common. While many patients reported CIAS-related burdens, a substantial proportion of them were unaware of CIAS. These observations indicate that the greater awareness of CIAS may facilitate its management in clinical practice, thus enhancing the ability of patients to reintegrate into society.
本研究评估了日本精神分裂症相关认知障碍（CIAS）的知晓情况、管理情况及负担。2023年4月至12月开展了一项在线非干预性横断面研究，涉及149名精神科医生和852名患者。精神科医生将疾病急性期控制阳性症状列为优先事项，而在维持/稳定期则将改善社会功能作为首要任务。CIAS的管理被认为对患者重新融入社会最为重要。精神科医生报告称，住院患者中CIAS的发生率高于门诊患者。虽然72%的精神科医生评估了CIAS，但只有15%的医生使用了《精神分裂症认知简短评估量表》。此外，58%的精神科医生报告称，其患者中≤40%接受了CIAS干预。68%的患者报告有当前或既往CIAS经历。最常见的与CIAS相关的负担是“无法完成以前能做的任务或完成任务所需时间更长”（65%）和“无法保持注意力”（64%）。在目前未经历CIAS的患者（n = 496）中，分别有52%和50%报告了这些负担。尽管精神科医生普遍认识到CIAS，但使用适当评估工具和干预措施的情况并不常见。虽然许多患者报告了与CIAS相关的负担，但其中很大一部分人并未意识到CIAS。这些观察结果表明，对CIAS有更高的认知可能有助于在临床实践中对其进行管理，从而增强患者重新融入社会的能力。
