Kobayashi N H, King J C
Am J Hosp Pharm. 1977 Jun;34(6):589-94.
The compatibility of common additives in protein hydrolysate/dextrose solutions was studied. The additives included electrolytes (calcium gluconate, potassium phosphate and magnesium sulfate), vitamins (M.V.I., Solu B Forte, phytonadione, cyanocobalamin and folic acid), insulin and heparin sodium. Various concentrations of the admixtures were observed at intervals throughout a 24-hour period. Combinations which displayed no physical change were subjected to spectrophotometric analysis. Thin-layer chromatography was used to examine those mixtures which displayed a spectral change. The principal incompatibility problems are related to concentrations of calcium gluconate and potassium phosphate. The order of mixing affected the concentration tolerances. The vitamins, insulin, heparin and magnesium, in usual therapeutic concentrations, appeared to be compatible in the protein hydrolysate/dextrose solution.
研究了蛋白质水解物/葡萄糖溶液中常见添加剂的相容性。添加剂包括电解质（葡萄糖酸钙、磷酸钾和硫酸镁）、维生素（多种维生素注射剂、复合维生素B注射液、维生素K1、维生素B12和叶酸）、胰岛素和肝素钠。在24小时内定期观察各种浓度的混合物。对无物理变化的组合进行分光光度分析。用薄层色谱法检测有光谱变化的混合物。主要的不相容问题与葡萄糖酸钙和磷酸钾的浓度有关。混合顺序影响浓度耐受性。在通常治疗浓度下，维生素、胰岛素、肝素和镁在蛋白质水解物/葡萄糖溶液中似乎是相容的。
