Liu Xiaozhen, Wei Zhiyan, Yang Mingming, Zhang Xiaoxue, Wang Zhuo, Li Shuyu, Li Changfu, Zhu Lingfang, Zhang Lei, Zhang Xiaoqing, Shen Xihui
Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
Institute of Grassland Research, Chinese Academy of Agricultural Sciences, Hohhot 010010, China.
iScience. 2025 Jun 13;28(7):112908. doi: 10.1016/j.isci.2025.112908. eCollection 2025 Jul 18.
Animal communication within a community is essential for their survival and reproduction. This phenomenon is not restricted to animals but is also prevalent in prokaryotes, which employ quorum sensing (QS) mechanisms for communication and behavior. Despite their importance, cell-cell communication in prokaryotes has not been cataloged in detail. Therefore, we developed a comprehensive map of cell-cell microbial communication by analyzing 15,297 prokaryotic genomes, thereby expanding the scope of the AI-2 signal in the microbiome. We showed that LsrB receptors are found in 15 bacterial phyla and can regulate the expression of genes involved in the biosynthesis of siderophore group nonribosomal peptides and biofilm formation via LsrB in . We also conducted an international prospective study of microbial communication models across distinct habitats. These findings highlight the importance of microbial communication and will enable comprehensive studies of large-scale microbial communities, greatly expanding our understanding of AI-2 in the microbial consortium.
群体内的动物交流对于它们的生存和繁殖至关重要。这种现象不仅限于动物，在原核生物中也很普遍，原核生物利用群体感应（QS）机制进行交流和行为。尽管它们很重要，但原核生物中的细胞间通讯尚未得到详细编目。因此，我们通过分析15297个原核生物基因组，绘制了一张全面的细胞间微生物通讯图谱，从而扩大了微生物群落中AI-2信号的范围。我们发现LsrB受体存在于15个细菌门中，并可以通过LsrB调节参与铁载体类非核糖体肽生物合成和生物膜形成的基因的表达。我们还对不同栖息地的微生物通讯模型进行了一项国际前瞻性研究。这些发现突出了微生物通讯的重要性，并将有助于对大规模微生物群落进行全面研究，极大地扩展我们对微生物群落中AI-2的理解。
