Department of Psychology, School of Social Development and Public Policy, Fudan University, Shanghai, China.
Department of Sports Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
PLoS One. 2023 Apr 7;18(4):e0284228. doi: 10.1371/journal.pone.0284228. eCollection 2023.
Inflammaging, a chronic low-grade inflammation, is considered as the basis of age-related diseases. Mindfulness is involved in protecting telomeres, whose shortening causes aging. This paper reports a protocol for the meta-analysis and systematic review to bond the causality between the mindfulness practices and inflammaging responses according to the data collected from the relevant observational studies.
The published studies during 2006-2023 will be identified from PubMed, Web of Science, Cochrane Central Register of Controlled Trials, and ProQuest Dissertation & Theses Global. The retrieved records will be screened independently by two researchers, and the relevant data will be extracted after reaching an agreement. The eligible studies will be analyzed with both of a meta-analysis and a narrative review. The risk of bias will be evaluated according to the Cochrane assessment for risk of biases. In the meta-analysis, random models will be applied to evaluate the effectiveness of mindfulness-based interventions on inflammaging due to the variation among studies. The dppc2 and Cohen's d will be calculated for synthesizing the evidences from the randomized controlled trials and intervention programs without a pretest-posttest design, respectively. The interstudy heterogeneity will be assessed with the Q test and quantified using I2 statistic. The subgroup analyses will be conducted against the categorical moderators and meta-regressions against the continuous ones. A narrative review will be recruited to deepen the understanding of the primary outcomes, in which consequential covariates with limited data in the bulk of reports will be included.
PROSPERO registration number CRD42022321766.
炎症衰老被认为是与年龄相关疾病的基础，是一种慢性低度炎症。正念涉及保护端粒，端粒缩短会导致衰老。本文报告了一项荟萃分析和系统评价方案，根据从相关观察性研究中收集的数据，将正念练习与炎症衰老反应之间的因果关系联系起来。
将从 PubMed、Web of Science、Cochrane 中央对照试验注册中心和 ProQuest 学位论文与全球检索 2006 年至 2023 年期间发表的研究。由两名研究人员独立筛选检索到的记录，并在达成一致后提取相关数据。将对合格研究进行荟萃分析和叙述性综述分析。根据 Cochrane 评估偏倚风险对偏倚风险进行评估。在荟萃分析中，由于研究之间的差异，将应用随机模型来评估基于正念的干预对炎症衰老的效果。对于没有预测试后设计的随机对照试验和干预方案，将分别计算 dppc2 和 Cohen's d 来综合证据。将使用 Q 检验评估研究间异质性，并使用 I2 统计量量化。将进行分类变量的亚组分析和连续变量的荟萃回归分析。叙述性综述将用于深入了解主要结果，其中报告中数据有限的后续协变量将被纳入。
PROSPERO 注册号 CRD42022321766。
