非编码RNA与非小细胞肺癌中的Hippo信号通路：作为生物标志物和治疗靶点的新作用

Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets.

作者信息

Joulani Mohammadamin, Aghajamal Nahal, Nouri Masoumeh, Khajeh Faraz Rahmani, Sharifi Nafiseh, Saghafi Dena, Amiri Mahan, Abdollahzadeh Ali, Heidari Ehsan, Mirdamadian Amin, Sharafi Malihe, Masoumi Samira, Morovatshoar Reza, Azani Alireza, Behfar Qumars

机构信息

Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, 009821, Iran.

Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 00984, Iran.

出版信息

Discov Oncol. 2025 Jul 18;16(1):1365. doi: 10.1007/s12672-025-03099-6.

DOI:10.1007/s12672-025-03099-6

PMID:40679672

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12274179/

Abstract

The most common type of cancer and one with a high death rate is lung cancer, especially non-small cell lung cancer (NSCLC), which is mostly brought on by medication resistance, metastasis, and delayed diagnosis. The discovery of non-coding RNAs (ncRNAs), such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs), has revealed their vital involvement in the pathophysiology of lung cancer by controlling important cellular processes. The Hippo signaling pathway is one of the critical routes impacted by non-coding RNAs. It is involved in tumor suppression, apoptosis, and cell proliferation. The interaction between ncRNAs and the Hippo pathway in lung cancer is reviewed in this review, with an emphasis on the potential of these molecules as therapeutic targets as well as diagnostic and prognostic biomarkers.

摘要

最常见且死亡率高的癌症类型是肺癌，尤其是非小细胞肺癌（NSCLC），其主要由耐药性、转移和诊断延迟引起。非编码RNA（ncRNA）的发现，如环状RNA（circRNA）、长链非编码RNA（lncRNA）和微小RNA（miRNA），揭示了它们通过控制重要的细胞过程在肺癌病理生理学中发挥的关键作用。Hippo信号通路是非编码RNA影响的关键途径之一。它参与肿瘤抑制、细胞凋亡和细胞增殖。本文综述了ncRNA与肺癌中Hippo通路之间的相互作用，重点关注这些分子作为治疗靶点以及诊断和预后生物标志物的潜力。