de Oliveira Ramos João Victor, Andrade Fernandes João Vitor, de Oliveira Ferreira Carlos Henrique, Gadelha de Abrantes Formiga Yan, de Lacerda Dantas Henrique Gabrielle, Lacerda de Souza Ramon, Esberard de Lima Beltrão Fabyan
Federal University of Paraíba, João Pessoa, Brazil.
Federal University of Rio Grande do Norte, Natal, Brazil.
Obes Surg. 2025 Jul 18. doi: 10.1007/s11695-025-08077-z.
Bariatric surgery is effective for treating obesity and its comorbidities, but the optimal technique remains debated. This meta-analysis compared one-anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) in comorbidity remission and postoperative outcomes. We analyzed 12 trials, assessing T2DM, hypertension, and sleep apnea remission, as well as postoperative complications. Statistical analyses included risk differences (RD) and risk ratios (RR). OAGB was non-inferior to RYGB for T2DM remission (RD -1%; 95% CI -10% to 8%) but had higher risks of bile reflux (RR 7.62; 95% CI 1.97-29.46) and de novo GERD (RR 5.10; 95% CI 1.44-18.00). While OAGB is effective for T2DM remission, RYGB is superior in reducing bile reflux and GERD, highlighting the need for individualized surgical approaches.
减肥手术对于治疗肥胖症及其合并症是有效的，但最佳技术仍存在争议。这项荟萃分析比较了单吻合口胃旁路术（OAGB）和 Roux-en-Y 胃旁路术（RYGB）在合并症缓解和术后结果方面的差异。我们分析了 12 项试验，评估了 2 型糖尿病、高血压和睡眠呼吸暂停的缓解情况以及术后并发症。统计分析包括风险差异（RD）和风险比（RR）。在 2 型糖尿病缓解方面，OAGB 不劣于 RYGB（RD -1%；95% CI -10%至 8%），但胆汁反流风险（RR 7.62；95% CI 1.97 - 29.46）和新发胃食管反流病（RR 5.10；95% CI 1.44 - 18.00）更高。虽然 OAGB 对 2 型糖尿病缓解有效，但 RYGB 在减少胆汁反流和胃食管反流病方面更具优势，这突出了个体化手术方法的必要性。
