应用行为测试评估雌性大鼠阿尔茨海默病实验模型。
Application of Behavioral Tests for Evaluation of an Experimental Model of Alzheimer's Disease in Female Rats.
机构信息
V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2023 May;175(1):126-131. doi: 10.1007/s10517-023-05823-0. Epub 2023 Jun 19.
Alzheimer's disease was modeled in female Wistar rats aged 4 months by stereotaxic bilateral injection of a synthetic peptide β-amyloid (Aβ1-42) into the hippocampus. Behavioral tests (open field, Y-maze, passive avoidance, and Morris water maze) revealed significant impairment of memory and spatial navigation 8 weeks after β-amyloid administration. At this term, the cognitive impairments typical of Alzheimer's disease are reproduced. The experimental model of Alzheimer's disease proposed by us can be used in preclinical studies of drugs for the treatment of this pathology.
阿尔茨海默病模型是通过立体定向双侧向 Wistar 雌性大鼠海马内注射合成肽β-淀粉样蛋白（Aβ1-42）建立的。行为测试（旷场、Y 迷宫、被动回避和 Morris 水迷宫）显示，β-淀粉样蛋白给药 8 周后，记忆和空间导航能力显著受损。在这个时期，会重现阿尔茨海默病的典型认知障碍。我们提出的阿尔茨海默病实验模型可用于该病理治疗药物的临床前研究。
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