Zheng Lifan, Zhu Zilan, Pan Longhui, Zhong Liang, Xiao Siyu, Zhao Chan, Liu Yao, Xu Jian, Zhang Yongping
College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Int J Biol Macromol. 2025 Aug;320(Pt 4):145960. doi: 10.1016/j.ijbiomac.2025.145960. Epub 2025 Jul 17.
Electrospinning nanofibers possesses several properties that enhance wound healing and are widely utilized in wound dressings. Most natural polymers, including a variety of polysaccharides and proteins such as chitosan, hyaluronic acid, silk fibroin, collagen, alginate, and zein, have good biocompatibility and abundant bioactivity and are considered beneficial materials for promoting wound healing. However, natural polymers' stability and mechanical properties are poor, affecting their application in electrospinning to a certain extent. This paper first introduces the wound healing process and electrospinning types, then focuses on the characteristics of several natural polymers and their role in promoting wound healing, pays attention to the problems and solutions of their preparation of nanofibers, and finally summarizes the crosslinking methods of natural polymers electrospinning nanofibers.
静电纺丝纳米纤维具有多种促进伤口愈合的特性，被广泛应用于伤口敷料中。大多数天然聚合物，包括各种多糖和蛋白质，如壳聚糖、透明质酸、丝素蛋白、胶原蛋白、藻酸盐和玉米醇溶蛋白，具有良好的生物相容性和丰富的生物活性，被认为是促进伤口愈合的有益材料。然而，天然聚合物的稳定性和机械性能较差，在一定程度上影响了它们在静电纺丝中的应用。本文首先介绍伤口愈合过程和静电纺丝类型，然后重点阐述几种天然聚合物的特性及其在促进伤口愈合中的作用，关注其制备纳米纤维的问题及解决方案，最后总结天然聚合物静电纺丝纳米纤维的交联方法。
